| http://purl.uniprot.org/citations/17050724 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17050724 | http://www.w3.org/2000/01/rdf-schema#comment | "It has been long believed that the anteroposterior (A-P) and dorsoventral (D-V) axes in the developing retina are determined independently and also that the retinotectal projection along the two axes is controlled independently. However, we recently demonstrated that misexpression of Ventroptin, a bone morphogenic protein (BMP) antagonist, in the developing chick retina alters the retinotectal projection not only along the D-V (or mediolateral) axis but also along the A-P axis. Moreover, the dorsal-high expression of BMP4 is relieved by the dorsotemporal-high expression of BMP2 at embryonic day 5 (E5) in the retina, during which Ventroptin continuously counteracts the two BMPs keeping on the countergradient expression pattern, respectively. Here, we show that the topographic molecules so far reported to have a gradient only along the D-V axis and ephrin-A2 so far only along the A-P axis are both controlled by the BMP signal, and that they are expressed in a gradient manner along the tilted axis from E6 on in the developing chick retina: the expression patterns of these oblique-gradient molecules are all changed, when BMP2 expression is manipulated in the developing retina. Furthermore, in both BMP2 knockdown embryos and ephrin-A2-misexpressed embryos, the retinotectal projection is altered along the two orthogonal axes. The expressional switching from BMP4 to BMP2 thus appears to play a key role in the retinal patterning and topographic retinotectal projection by tilting the D-V axis toward the posterior side during retinal development. Our results also indicate that BMP2 expression is essential for the maintenance of regional specificity along the revised D-V axis."xsd:string |
| http://purl.uniprot.org/citations/17050724 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.3027-06.2006"xsd:string |
| http://purl.uniprot.org/citations/17050724 | http://purl.uniprot.org/core/author | "Takahashi H."xsd:string |
| http://purl.uniprot.org/citations/17050724 | http://purl.uniprot.org/core/author | "Noda M."xsd:string |
| http://purl.uniprot.org/citations/17050724 | http://purl.uniprot.org/core/author | "Shintani T."xsd:string |
| http://purl.uniprot.org/citations/17050724 | http://purl.uniprot.org/core/author | "Sakuta H."xsd:string |
| http://purl.uniprot.org/citations/17050724 | http://purl.uniprot.org/core/author | "Etani K."xsd:string |
| http://purl.uniprot.org/citations/17050724 | http://purl.uniprot.org/core/author | "Aoshima A."xsd:string |
| http://purl.uniprot.org/citations/17050724 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17050724 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/17050724 | http://purl.uniprot.org/core/pages | "10868-10878"xsd:string |
| http://purl.uniprot.org/citations/17050724 | http://purl.uniprot.org/core/title | "Role of bone morphogenic protein 2 in retinal patterning and retinotectal projection."xsd:string |
| http://purl.uniprot.org/citations/17050724 | http://purl.uniprot.org/core/volume | "26"xsd:string |
| http://purl.uniprot.org/citations/17050724 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17050724 |
| http://purl.uniprot.org/citations/17050724 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17050724 |
| http://purl.uniprot.org/uniprot/#_Q6XDQ0-mappedCitation-17050724 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17050724 |
| http://purl.uniprot.org/uniprot/#_Q90751-mappedCitation-17050724 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17050724 |
| http://purl.uniprot.org/uniprot/Q6XDQ0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17050724 |
| http://purl.uniprot.org/uniprot/Q90751 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17050724 |