| http://purl.uniprot.org/citations/17052889 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17052889 | http://www.w3.org/2000/01/rdf-schema#comment | "We had earlier hypothesized, if parents originated from previously isolated populations that had selected against different critical susceptibility genes for a polygenic disease, their offspring could have a greater risk of that disease than either parent. We therefore studied parents of patients with type 1 diabetes (T1D). We found that parents who transmitted HLA-DR3 to HLA-DR3/DR4 patients had different HLA-A allele frequencies on the non-transmitted HLA haplotype than HLA-DR4-transmitters. HLA-DR3-positive parents also had different insulin (INS) gene allele frequencies than HLA-DR4-positive parents. Parent pairs of patients had greater self-reported ethnicity disparity than parent pairs in control families. Although there was an excess of HLA-DR3/DR4 heterozygotes among type 1 diabetes patients, there were significantly fewer HLA-DR3/DR4 heterozygous parents of patients than expected. These findings are consistent with HLA-DR and INS VNTR alleles marking both disease susceptibility and separate Caucasian parental subpopulations. Our hypothesis thus explains some seemingly disconnected puzzling phenomena, including (1) the rising world-wide incidence of T1D, (2) the excess of HLA-DR3/DR4 heterozygotes among patients, (3) the changing frequency of HLA-DR3/DR4 heterozygotes and of susceptibility alleles in general in patients over the past several decades, and (4) the association of INS alleles with specific HLA-DR alleles in patients with T1D."xsd:string |
| http://purl.uniprot.org/citations/17052889 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.jaut.2006.08.004"xsd:string |
| http://purl.uniprot.org/citations/17052889 | http://purl.uniprot.org/core/author | "Larsen C.E."xsd:string |
| http://purl.uniprot.org/citations/17052889 | http://purl.uniprot.org/core/author | "Pugliese A."xsd:string |
| http://purl.uniprot.org/citations/17052889 | http://purl.uniprot.org/core/author | "Yunis E.J."xsd:string |
| http://purl.uniprot.org/citations/17052889 | http://purl.uniprot.org/core/author | "Alper C.A."xsd:string |
| http://purl.uniprot.org/citations/17052889 | http://purl.uniprot.org/core/author | "Awdeh Z.L."xsd:string |
| http://purl.uniprot.org/citations/17052889 | http://purl.uniprot.org/core/author | "Fici D."xsd:string |
| http://purl.uniprot.org/citations/17052889 | http://purl.uniprot.org/core/author | "Audeh M.J."xsd:string |
| http://purl.uniprot.org/citations/17052889 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17052889 | http://purl.uniprot.org/core/name | "J Autoimmun"xsd:string |
| http://purl.uniprot.org/citations/17052889 | http://purl.uniprot.org/core/pages | "174-181"xsd:string |
| http://purl.uniprot.org/citations/17052889 | http://purl.uniprot.org/core/title | "A genetic explanation for the rising incidence of type 1 diabetes, a polygenic disease."xsd:string |
| http://purl.uniprot.org/citations/17052889 | http://purl.uniprot.org/core/volume | "27"xsd:string |
| http://purl.uniprot.org/citations/17052889 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17052889 |
| http://purl.uniprot.org/citations/17052889 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17052889 |
| http://purl.uniprot.org/uniprot/#_A0A0P1GLA1-mappedCitation-17052889 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17052889 |
| http://purl.uniprot.org/uniprot/#_A0A0P1JEH2-mappedCitation-17052889 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17052889 |
| http://purl.uniprot.org/uniprot/#_D0AB36-mappedCitation-17052889 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17052889 |
| http://purl.uniprot.org/uniprot/#_D0AB37-mappedCitation-17052889 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17052889 |
| http://purl.uniprot.org/uniprot/#_D0RB86-mappedCitation-17052889 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17052889 |
| http://purl.uniprot.org/uniprot/#_A0A024F9S2-mappedCitation-17052889 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17052889 |
| http://purl.uniprot.org/uniprot/#_A0A1C8DXF2-mappedCitation-17052889 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17052889 |
| http://purl.uniprot.org/uniprot/#_A0A1L2BMT8-mappedCitation-17052889 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17052889 |