| http://purl.uniprot.org/citations/17055354 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17055354 | http://www.w3.org/2000/01/rdf-schema#comment | "A major milestone in transplantation would be the use of biomarkers to monitor rejection. We examined the association between perforin and granzyme-B gene expression detected in the peripheral blood of renal allograft recipients with cellular and antibody-mediated rejection. Furthermore, we judged the appropriateness of assigning negative rejection statuses to persons without a biopsy whose grafts were functioning well clinically. Of the 46 patients who completed the study, recipients with cellular rejection had higher perforin and granzyme-B levels compared with nonrejectors (p = 0.006). Interestingly, recipients with antibody-mediated rejection also had higher perforin and granzyme-B levels compared with nonrejectors (p = 0.04). Patients with high levels of granzyme B had a probability of rejecting that was 26.7 times greater than those patients with low levels of granzyme B. Perforin and granzyme B had sensitivities of 50% and specificities of 95% in predicting rejection (cutoff value = 140). Assigning negative rejection statuses to recipients without a biopsy whose grafts were functioning well did not have a major effect on the direction or significance of covariate values. This study suggests that perforin and granzyme-B gene expressions in peripheral blood are accurate in detecting both cellular and antibody-mediated rejection."xsd:string |
| http://purl.uniprot.org/citations/17055354 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.humimm.2006.07.006"xsd:string |
| http://purl.uniprot.org/citations/17055354 | http://purl.uniprot.org/core/author | "Du Z."xsd:string |
| http://purl.uniprot.org/citations/17055354 | http://purl.uniprot.org/core/author | "Jia J."xsd:string |
| http://purl.uniprot.org/citations/17055354 | http://purl.uniprot.org/core/author | "Zhang Q."xsd:string |
| http://purl.uniprot.org/citations/17055354 | http://purl.uniprot.org/core/author | "Qian L."xsd:string |
| http://purl.uniprot.org/citations/17055354 | http://purl.uniprot.org/core/author | "Braun J."xsd:string |
| http://purl.uniprot.org/citations/17055354 | http://purl.uniprot.org/core/author | "Reed E.F."xsd:string |
| http://purl.uniprot.org/citations/17055354 | http://purl.uniprot.org/core/author | "Pham P.T."xsd:string |
| http://purl.uniprot.org/citations/17055354 | http://purl.uniprot.org/core/author | "Lassman C.R."xsd:string |
| http://purl.uniprot.org/citations/17055354 | http://purl.uniprot.org/core/author | "Gjertson D.W."xsd:string |
| http://purl.uniprot.org/citations/17055354 | http://purl.uniprot.org/core/author | "Bloomquist E.W."xsd:string |
| http://purl.uniprot.org/citations/17055354 | http://purl.uniprot.org/core/author | "Danovitch G.M."xsd:string |
| http://purl.uniprot.org/citations/17055354 | http://purl.uniprot.org/core/author | "Gritsch H.A."xsd:string |
| http://purl.uniprot.org/citations/17055354 | http://purl.uniprot.org/core/author | "Liang L.W."xsd:string |
| http://purl.uniprot.org/citations/17055354 | http://purl.uniprot.org/core/author | "Rosenthal J.T."xsd:string |
| http://purl.uniprot.org/citations/17055354 | http://purl.uniprot.org/core/author | "Veale J.L."xsd:string |
| http://purl.uniprot.org/citations/17055354 | http://purl.uniprot.org/core/author | "Wilkinson A.H."xsd:string |
| http://purl.uniprot.org/citations/17055354 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17055354 | http://purl.uniprot.org/core/name | "Hum Immunol"xsd:string |
| http://purl.uniprot.org/citations/17055354 | http://purl.uniprot.org/core/pages | "777-786"xsd:string |
| http://purl.uniprot.org/citations/17055354 | http://purl.uniprot.org/core/title | "Noninvasive diagnosis of cellular and antibody-mediated rejection by perforin and granzyme B in renal allografts."xsd:string |
| http://purl.uniprot.org/citations/17055354 | http://purl.uniprot.org/core/volume | "67"xsd:string |
| http://purl.uniprot.org/citations/17055354 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17055354 |