| http://purl.uniprot.org/citations/17055754 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17055754 | http://www.w3.org/2000/01/rdf-schema#comment | "While T cells respond directly to toll-like receptor (TLR) agonists, TLR-signaling pathways in T cells are poorly characterized. Here we demonstrate in CD4(+) T cells that CpG DNA directly enhances proliferation, prevents anergy, and augments humoral responses to a T cell-dependent antigen by a Myeloid differentiation primary-response protein 88 (MyD88) and Phosphatidylinositol 3-kinase (PI-3 kinase)-dependent pathway. PI-3 kinase activation required a putative Src-homology domain (SH2) binding motif in the MyD88 Toll-Like or IL-1 Receptor (TIR) domain. Reconstitution of MyD88-deficient primary T cells with a MyD88 transgene mutated in this motif abrogated association of PI-3 kinase with MyD88, phosphorylation of protein kinase B (Akt) and Glycogen Synthetase Kinase-3 (GSK-3), and interleukin-2 (IL-2) production. The MyD88 death domain, on the other hand, was required for NF-kB activation and survival. These studies identify a MyD88-dependent PI-3 kinase-signaling pathway in T cells that differentiates CpG DNA-mediated proliferation from survival and is required for an in vivo T cell-dependent immune response."xsd:string |
| http://purl.uniprot.org/citations/17055754 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2006.08.023"xsd:string |
| http://purl.uniprot.org/citations/17055754 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/17055754 | http://purl.uniprot.org/core/author | "Choi Y."xsd:string |
| http://purl.uniprot.org/citations/17055754 | http://purl.uniprot.org/core/author | "Turka L.A."xsd:string |
| http://purl.uniprot.org/citations/17055754 | http://purl.uniprot.org/core/author | "Sunyer J.O."xsd:string |
| http://purl.uniprot.org/citations/17055754 | http://purl.uniprot.org/core/author | "Walsh P.T."xsd:string |
| http://purl.uniprot.org/citations/17055754 | http://purl.uniprot.org/core/author | "Gelman A.E."xsd:string |
| http://purl.uniprot.org/citations/17055754 | http://purl.uniprot.org/core/author | "LaRosa D.F."xsd:string |
| http://purl.uniprot.org/citations/17055754 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17055754 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/17055754 | http://purl.uniprot.org/core/pages | "783-793"xsd:string |
| http://purl.uniprot.org/citations/17055754 | http://purl.uniprot.org/core/title | "The adaptor molecule MyD88 activates PI-3 kinase signaling in CD4+ T cells and enables CpG oligodeoxynucleotide-mediated costimulation."xsd:string |
| http://purl.uniprot.org/citations/17055754 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/17055754 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17055754 |
| http://purl.uniprot.org/citations/17055754 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17055754 |
| http://purl.uniprot.org/uniprot/#_Q0PM15-mappedCitation-17055754 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17055754 |
| http://purl.uniprot.org/uniprot/#_Q0PM16-mappedCitation-17055754 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17055754 |
| http://purl.uniprot.org/uniprot/#_A0A1S5WLE4-mappedCitation-17055754 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17055754 |
| http://purl.uniprot.org/uniprot/#_A0A1S5WLF0-mappedCitation-17055754 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17055754 |
| http://purl.uniprot.org/uniprot/#_F6SPW1-mappedCitation-17055754 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17055754 |
| http://purl.uniprot.org/uniprot/#_Q3TIB3-mappedCitation-17055754 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17055754 |
| http://purl.uniprot.org/uniprot/#_Q3UDG9-mappedCitation-17055754 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17055754 |
| http://purl.uniprot.org/uniprot/#_Q3U6W5-mappedCitation-17055754 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17055754 |