| http://purl.uniprot.org/citations/17062636 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17062636 | http://www.w3.org/2000/01/rdf-schema#comment | "Min mice provide a good model of human familial adenomatous polyposis. Recently, we have reported on two recombinant inbred lines (I and V) and the location of a modifier (Mom3) close to Apc, which altered polyp numbers in our mice possibly by modifying the frequency of wild-type (WT) allele loss at Apc; mice with severe disease (line V) showed elevated rates of loss. We now show that in line I only, a single pregnancy caused a significant increase in adenoma multiplicity compared with virgin controls (P<0.001) and that an additional pregnancy conferred a similar risk. Pregnancy was linked to both adenoma initiation and enhanced tumour growth in line I mice, and interline crosses indicated that susceptibility to pregnancy-associated adenomas was under genetic control. We found no evidence for the involvement of oestrodial metabolizing genes or the oestrogen receptors (Esr1 and 2) in tumour multiplicity. Importantly, a significantly elevated frequency of WT allele loss at Apc was observed in adenomas from parous mice (line and backcrossed) carrying the line I Min allele relative to equivalent virgin controls (P=0.015). Our results provide the first experimental evidence for genetic determinants controlling pregnancy-associated tumourigenesis; analogous genetic factors may exist in humans."xsd:string |
| http://purl.uniprot.org/citations/17062636 | http://purl.org/dc/terms/identifier | "doi:10.1093/hmg/ddl419"xsd:string |
| http://purl.uniprot.org/citations/17062636 | http://purl.uniprot.org/core/author | "Guenther T."xsd:string |
| http://purl.uniprot.org/citations/17062636 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/17062636 | http://purl.uniprot.org/core/author | "Rogers P."xsd:string |
| http://purl.uniprot.org/citations/17062636 | http://purl.uniprot.org/core/author | "Tomlinson I."xsd:string |
| http://purl.uniprot.org/citations/17062636 | http://purl.uniprot.org/core/author | "Polanco-Echeverry G."xsd:string |
| http://purl.uniprot.org/citations/17062636 | http://purl.uniprot.org/core/author | "Haines J."xsd:string |
| http://purl.uniprot.org/citations/17062636 | http://purl.uniprot.org/core/author | "Silver A."xsd:string |
| http://purl.uniprot.org/citations/17062636 | http://purl.uniprot.org/core/author | "Sieber O."xsd:string |
| http://purl.uniprot.org/citations/17062636 | http://purl.uniprot.org/core/author | "Coster M."xsd:string |
| http://purl.uniprot.org/citations/17062636 | http://purl.uniprot.org/core/author | "Suraweera N."xsd:string |
| http://purl.uniprot.org/citations/17062636 | http://purl.uniprot.org/core/author | "Latchford A."xsd:string |
| http://purl.uniprot.org/citations/17062636 | http://purl.uniprot.org/core/author | "McCart A."xsd:string |
| http://purl.uniprot.org/citations/17062636 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17062636 | http://purl.uniprot.org/core/name | "Hum Mol Genet"xsd:string |
| http://purl.uniprot.org/citations/17062636 | http://purl.uniprot.org/core/pages | "3429-3435"xsd:string |
| http://purl.uniprot.org/citations/17062636 | http://purl.uniprot.org/core/title | "Genetic determinants modulate susceptibility to pregnancy-associated tumourigenesis in a recombinant line of Min mice."xsd:string |
| http://purl.uniprot.org/citations/17062636 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/17062636 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17062636 |
| http://purl.uniprot.org/citations/17062636 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17062636 |
| http://purl.uniprot.org/uniprot/#_A0A1D5RLD6-mappedCitation-17062636 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17062636 |
| http://purl.uniprot.org/uniprot/#_P70694-mappedCitation-17062636 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17062636 |
| http://purl.uniprot.org/uniprot/#_A0A3B2W725-mappedCitation-17062636 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17062636 |