| http://purl.uniprot.org/citations/17068152 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17068152 | http://www.w3.org/2000/01/rdf-schema#comment | "Tumor necrosis factor-alpha (TNF-alpha) binds to 2 distinct cell-surface receptors: TNF-alpha receptor-I (TNFR-I: p55) and TNF-alpha receptor-II (TNFR-II: p75). TNF-alpha induces leukocyte adhesion molecules on endothelial cells (ECs), which mediate 3 defined steps of the inflammatory response; namely, leukocyte rolling, firm adhesion, and transmigration. In this study, we have investigated the role of p75 in TNF-alpha-induced leukocyte adhesion molecules using cultured ECs derived from wild-type (WT), p75-null (p75-/-), or p55-null (p55-/-) mice. We observed that p75 was essential for TNF-alpha-induced E-selectin, vascular cell adhesion molecule 1 (VCAM-1), and intercellular adhesion molecule 1 (ICAM-1) expression. We also investigated the putative role of p75 in inflammation in vivo using an intravital microscopic approach with a mouse cremaster muscle model. TNF-alpha-stimulated leukocyte rolling, firm adhesion to ECs, and transmigration were dramatically reduced in p75-/-mice. Transplanted WT cremaster in p75-/-mice showed a robust leukocyte rolling and firm adhesion upon TNF-alpha activation, suggesting that the impairment in EC-leukocyte interaction in p75-/-mice is due to EC dysfunction. These results demonstrate, for the first time, that endothelial p75 is essential for TNF-alpha-induced leukocyte-endothelial-cell interaction. Our findings may contribute to the identification of novel p75-targeted therapeutic approaches for inflammatory diseases."xsd:string |
| http://purl.uniprot.org/citations/17068152 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2006-05-020875"xsd:string |
| http://purl.uniprot.org/citations/17068152 | http://purl.uniprot.org/core/author | "Zhou Z."xsd:string |
| http://purl.uniprot.org/citations/17068152 | http://purl.uniprot.org/core/author | "Yang L."xsd:string |
| http://purl.uniprot.org/citations/17068152 | http://purl.uniprot.org/core/author | "Penn M."xsd:string |
| http://purl.uniprot.org/citations/17068152 | http://purl.uniprot.org/core/author | "Howe P.H."xsd:string |
| http://purl.uniprot.org/citations/17068152 | http://purl.uniprot.org/core/author | "DiCorleto P.E."xsd:string |
| http://purl.uniprot.org/citations/17068152 | http://purl.uniprot.org/core/author | "Bohn J."xsd:string |
| http://purl.uniprot.org/citations/17068152 | http://purl.uniprot.org/core/author | "Chandrasekharan U.M."xsd:string |
| http://purl.uniprot.org/citations/17068152 | http://purl.uniprot.org/core/author | "Ozer K."xsd:string |
| http://purl.uniprot.org/citations/17068152 | http://purl.uniprot.org/core/author | "Poptic E."xsd:string |
| http://purl.uniprot.org/citations/17068152 | http://purl.uniprot.org/core/author | "Siemionow M."xsd:string |
| http://purl.uniprot.org/citations/17068152 | http://purl.uniprot.org/core/author | "Unsal M."xsd:string |
| http://purl.uniprot.org/citations/17068152 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17068152 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/17068152 | http://purl.uniprot.org/core/pages | "1938-1944"xsd:string |
| http://purl.uniprot.org/citations/17068152 | http://purl.uniprot.org/core/title | "Tumor necrosis factor alpha (TNF-alpha) receptor-II is required for TNF-alpha-induced leukocyte-endothelial interaction in vivo."xsd:string |
| http://purl.uniprot.org/citations/17068152 | http://purl.uniprot.org/core/volume | "109"xsd:string |
| http://purl.uniprot.org/citations/17068152 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17068152 |
| http://purl.uniprot.org/citations/17068152 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17068152 |
| http://purl.uniprot.org/uniprot/#_D3YXL4-mappedCitation-17068152 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17068152 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J210-mappedCitation-17068152 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17068152 |
| http://purl.uniprot.org/uniprot/#_A0A0U5J4W4-mappedCitation-17068152 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17068152 |
| http://purl.uniprot.org/uniprot/#_D6RG55-mappedCitation-17068152 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17068152 |