| http://purl.uniprot.org/citations/17068255 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17068255 | http://www.w3.org/2000/01/rdf-schema#comment | "Large-conductance calcium- and voltage-activated potassium channels (BKCa) are dually activated by membrane depolarization and elevation of cytosolic calcium ions (Ca2+). Under normal cellular conditions, BKCa channel activation requires Ca2+ concentrations that typically occur in close proximity to Ca2+ sources. We show that BKCa channels affinity-purified from rat brain are assembled into macromolecular complexes with the voltage-gated calcium channels Cav1.2 (L-type), Cav2.1 (P/Q-type), and Cav2.2 (N-type). Heterologously expressed BKCa-Cav complexes reconstitute a functional "Ca2+ nanodomain" where Ca2+ influx through the Cav channel activates BKCa in the physiological voltage range with submillisecond kinetics. Complex formation with distinct Cav channels enables BKCa-mediated membrane hyperpolarization that controls neuronal firing pattern and release of hormones and transmitters in the central nervous system."xsd:string |
| http://purl.uniprot.org/citations/17068255 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1132915"xsd:string |
| http://purl.uniprot.org/citations/17068255 | http://purl.uniprot.org/core/author | "Klugbauer N."xsd:string |
| http://purl.uniprot.org/citations/17068255 | http://purl.uniprot.org/core/author | "Oliver D."xsd:string |
| http://purl.uniprot.org/citations/17068255 | http://purl.uniprot.org/core/author | "Schulte U."xsd:string |
| http://purl.uniprot.org/citations/17068255 | http://purl.uniprot.org/core/author | "Thumfart J.O."xsd:string |
| http://purl.uniprot.org/citations/17068255 | http://purl.uniprot.org/core/author | "Berkefeld H."xsd:string |
| http://purl.uniprot.org/citations/17068255 | http://purl.uniprot.org/core/author | "Rohde V."xsd:string |
| http://purl.uniprot.org/citations/17068255 | http://purl.uniprot.org/core/author | "Bildl W."xsd:string |
| http://purl.uniprot.org/citations/17068255 | http://purl.uniprot.org/core/author | "Fakler B."xsd:string |
| http://purl.uniprot.org/citations/17068255 | http://purl.uniprot.org/core/author | "Knaus H.G."xsd:string |
| http://purl.uniprot.org/citations/17068255 | http://purl.uniprot.org/core/author | "Eble S."xsd:string |
| http://purl.uniprot.org/citations/17068255 | http://purl.uniprot.org/core/author | "Sailer C.A."xsd:string |
| http://purl.uniprot.org/citations/17068255 | http://purl.uniprot.org/core/author | "Reisinger E."xsd:string |
| http://purl.uniprot.org/citations/17068255 | http://purl.uniprot.org/core/author | "Bischofberger J."xsd:string |
| http://purl.uniprot.org/citations/17068255 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17068255 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/17068255 | http://purl.uniprot.org/core/pages | "615-620"xsd:string |
| http://purl.uniprot.org/citations/17068255 | http://purl.uniprot.org/core/title | "BKCa-Cav channel complexes mediate rapid and localized Ca2+-activated K+ signaling."xsd:string |
| http://purl.uniprot.org/citations/17068255 | http://purl.uniprot.org/core/volume | "314"xsd:string |
| http://purl.uniprot.org/citations/17068255 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17068255 |
| http://purl.uniprot.org/citations/17068255 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17068255 |
| http://purl.uniprot.org/uniprot/P54282#attribution-978CBA478AD5FD8784142C68CB0124CE | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17068255 |
| http://purl.uniprot.org/uniprot/P22002#attribution-978CBA478AD5FD8784142C68CB0124CE | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17068255 |