| http://purl.uniprot.org/citations/1706975 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1706975 | http://www.w3.org/2000/01/rdf-schema#comment | "The X1R chromosome of Drosophila miranda and the 3L autosome of Drosophila melanogaster are thought to have originated from the ancestral D chromosomal element and therefore may contain the same set of genes. It is expected that these genes will be dosage compensated in D. miranda because of their X linkage. To test these possibilities and to study evolution of the dosage compensation mechanism, we used the 3L-linked autosomal head-specific gene 507 ml of D. melanogaster to isolate the homologous gene (507mr) from a D. miranda genomic library. In situ hybridization showed that gene 507 is located at the 12A region of the X1R chromosome of D. miranda, indicating that the chromosomal homology deduced by cytogenetic means is correct. Restriction analysis and cross-specific DNA and RNA blot hybridization revealed the presence of extensive restriction pattern polymorphism and lack of sequence similarity in some areas of the 507mr and 507 ml DNA, including the 3' portion of the transcribed region. However, the 5' portion of the transcribed region and the DNA sequences, located approximately 0.8 kb upstream and 3 kb downstream from the 507 ml gene showed a high degree of similarity with the DNA sequences of comparable regions of the 507mr gene. In both species gene 507 codes for a highly abundant 1.8 kb RNA which is expressed in the retina of the compound eye. Although in D. miranda the males have one and the females have two copies of the 507 gene, the steady-state levels of the 507 mRNA in both sexes were found to be similar, indicating that gene 507 is dosage compensated in D. miranda.(ABSTRACT TRUNCATED AT 250 WORDS)"xsd:string |
| http://purl.uniprot.org/citations/1706975 | http://purl.org/dc/terms/identifier | "doi:10.1007/bf00418246"xsd:string |
| http://purl.uniprot.org/citations/1706975 | http://purl.uniprot.org/core/author | "Ganguly R."xsd:string |
| http://purl.uniprot.org/citations/1706975 | http://purl.uniprot.org/core/author | "Swanson K.D."xsd:string |
| http://purl.uniprot.org/citations/1706975 | http://purl.uniprot.org/core/author | "Krishnan R."xsd:string |
| http://purl.uniprot.org/citations/1706975 | http://purl.uniprot.org/core/date | "1991"xsd:gYear |
| http://purl.uniprot.org/citations/1706975 | http://purl.uniprot.org/core/name | "Chromosoma"xsd:string |
| http://purl.uniprot.org/citations/1706975 | http://purl.uniprot.org/core/pages | "125-133"xsd:string |
| http://purl.uniprot.org/citations/1706975 | http://purl.uniprot.org/core/title | "Dosage compensation of a retina-specific gene in Drosophila miranda."xsd:string |
| http://purl.uniprot.org/citations/1706975 | http://purl.uniprot.org/core/volume | "100"xsd:string |
| http://purl.uniprot.org/citations/1706975 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/1706975 |
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