| http://purl.uniprot.org/citations/17071854 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17071854 | http://www.w3.org/2000/01/rdf-schema#comment | "Laminin-5 (laminin-332) is an important basement membrane protein that regulates cell attachment and motility. Recent studies have shown that laminin-5 is expressed in human mesenchymal stem cells (MSCs) in culture and that the laminin gamma2 chain is transiently expressed in chondrocytes during development. These studies suggest that laminin-5 may be involved in the regulation of chondrogenic differentiation of MSCs. In this study, we examined a possible role of laminin-5 in the proliferation and differentiation of human MSCs. When MSCs were incubated in the presence of a coated or soluble form of laminin-5 in a growth medium, they proliferated more rapidly than nontreated cells, keeping their differentiation potential. On the other hand, laminin-5 potently suppressed the chondrogenic differentiation of MSCs. These activities were mediated mainly by integrin alpha3beta1. However, laminin-5 had no effect on the osteogenic differentiation of MSCs. These results suggest that laminin-5 may contribute to the development of bone tissues by promoting the proliferation and by suppressing the chondrogenic differentiation of MSCs."xsd:string |
| http://purl.uniprot.org/citations/17071854 | http://purl.org/dc/terms/identifier | "doi:10.1634/stemcells.2005-0605"xsd:string |
| http://purl.uniprot.org/citations/17071854 | http://purl.uniprot.org/core/author | "Kariya Y."xsd:string |
| http://purl.uniprot.org/citations/17071854 | http://purl.uniprot.org/core/author | "Miyazaki K."xsd:string |
| http://purl.uniprot.org/citations/17071854 | http://purl.uniprot.org/core/author | "Hashimoto J."xsd:string |
| http://purl.uniprot.org/citations/17071854 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17071854 | http://purl.uniprot.org/core/name | "Stem Cells"xsd:string |
| http://purl.uniprot.org/citations/17071854 | http://purl.uniprot.org/core/pages | "2346-2354"xsd:string |
| http://purl.uniprot.org/citations/17071854 | http://purl.uniprot.org/core/title | "Regulation of proliferation and chondrogenic differentiation of human mesenchymal stem cells by laminin-5 (laminin-332)."xsd:string |
| http://purl.uniprot.org/citations/17071854 | http://purl.uniprot.org/core/volume | "24"xsd:string |
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| http://purl.uniprot.org/uniprot/#_A0A0A0MSA0-mappedCitation-17071854 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17071854 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YYF2-mappedCitation-17071854 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17071854 |
| http://purl.uniprot.org/uniprot/#_A0A0A0MTS5-mappedCitation-17071854 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17071854 |
| http://purl.uniprot.org/uniprot/#_A0PJJ8-mappedCitation-17071854 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17071854 |
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| http://purl.uniprot.org/uniprot/#_Q59HA6-mappedCitation-17071854 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17071854 |