| http://purl.uniprot.org/citations/17072303 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17072303 | http://www.w3.org/2000/01/rdf-schema#comment | "Accumulating evidence indicates that hyperactive Wnt signalling occurs in association with the development and progression of human breast cancer. As a consequence of engaging the canonical Wnt pathway, a beta-catenin-T-cell factor (TCF) transcriptional complex is generated, which has been postulated to trigger the epithelial-mesenchymal transition (EMT) that characterizes the tissue-invasive phenotype. However, the molecular mechanisms by which the beta-catenin-TCF complex induces EMT-like programmes remain undefined. Here, we demonstrate that canonical Wnt signalling engages tumour cell dedifferentiation and tissue-invasive activity through an Axin2-dependent pathway that stabilizes the Snail1 zinc-transcription factor, a key regulator of normal and neoplastic EMT programmes. Axin2 regulates EMT by acting as a nucleocytoplasmic chaperone for GSK3beta, the dominant kinase responsible for controlling Snail1 protein turnover and activity. As dysregulated Wnt signalling marks a diverse array of cancerous tissue types, the identification of a beta-catenin-TCF-regulated Axin2-GSK3beta-Snail1 axis provides new mechanistic insights into cancer-associated EMT programmes."xsd:string |
| http://purl.uniprot.org/citations/17072303 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb1508"xsd:string |
| http://purl.uniprot.org/citations/17072303 | http://purl.uniprot.org/core/author | "Kim H.S."xsd:string |
| http://purl.uniprot.org/citations/17072303 | http://purl.uniprot.org/core/author | "Kim J."xsd:string |
| http://purl.uniprot.org/citations/17072303 | http://purl.uniprot.org/core/author | "Hu C."xsd:string |
| http://purl.uniprot.org/citations/17072303 | http://purl.uniprot.org/core/author | "Kim N.H."xsd:string |
| http://purl.uniprot.org/citations/17072303 | http://purl.uniprot.org/core/author | "Li X.Y."xsd:string |
| http://purl.uniprot.org/citations/17072303 | http://purl.uniprot.org/core/author | "Choi Y.J."xsd:string |
| http://purl.uniprot.org/citations/17072303 | http://purl.uniprot.org/core/author | "Weiss S.J."xsd:string |
| http://purl.uniprot.org/citations/17072303 | http://purl.uniprot.org/core/author | "Fearon E.R."xsd:string |
| http://purl.uniprot.org/citations/17072303 | http://purl.uniprot.org/core/author | "Ota I."xsd:string |
| http://purl.uniprot.org/citations/17072303 | http://purl.uniprot.org/core/author | "Yook J.I."xsd:string |
| http://purl.uniprot.org/citations/17072303 | http://purl.uniprot.org/core/author | "Ryu J.K."xsd:string |
| http://purl.uniprot.org/citations/17072303 | http://purl.uniprot.org/core/author | "Cha S.Y."xsd:string |
| http://purl.uniprot.org/citations/17072303 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17072303 | http://purl.uniprot.org/core/name | "Nat Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/17072303 | http://purl.uniprot.org/core/pages | "1398-1406"xsd:string |
| http://purl.uniprot.org/citations/17072303 | http://purl.uniprot.org/core/title | "A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells."xsd:string |
| http://purl.uniprot.org/citations/17072303 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/17072303 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17072303 |
| http://purl.uniprot.org/citations/17072303 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17072303 |
| http://purl.uniprot.org/uniprot/Q9Y2T1#attribution-12B9F58B210FABAE9518BF1C38D2D0B3 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17072303 |
| http://purl.uniprot.org/uniprot/Q9Y2T1#attribution-363FE198E7835CEC0F1D18F7D6AF1981 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17072303 |
| http://purl.uniprot.org/uniprot/P35222#attribution-363FE198E7835CEC0F1D18F7D6AF1981 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17072303 |