| http://purl.uniprot.org/citations/17074809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17074809 | http://www.w3.org/2000/01/rdf-schema#comment | "Emerging evidence supports the idea that the c-Jun N-terminal kinases (JNKs) possess overlapping but distinct functions. The potential roles of the ubiquitously expressed JNK1 and JNK2 in regulating expression of the central transcription initiation factor, TATA-binding protein (TBP), were examined. Relative to wild-type fibroblasts, TBP was decreased in Jnk1(-/-) cells and increased in Jnk2(-/-) cells. Similarly, reduction of JNK1 in human hepatoma cells decreased TBP expression, whereas reduction of JNK2 enhanced it. JNK-mediated regulation of TBP expression occurs at the transcriptional level through their ability to target Elk-1, which directly regulates the TBP promoter in response to epidermal growth factor stimulation. JNK1 increases, whereas JNK2 decreases, the phosphorylation state of Elk-1, which differentially affects Elk-1 occupancy at a defined site within the TBP promoter. These JNK-mediated alterations in TBP expression, alone, serve to regulate c-Jun expression and fibroblast proliferation rates. These studies uncovered several new molecular events that distinguish the functions of JNK1 and JNK2 that are critical for their regulation of cellular proliferation."xsd:string |
| http://purl.uniprot.org/citations/17074809 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.01365-06"xsd:string |
| http://purl.uniprot.org/citations/17074809 | http://purl.uniprot.org/core/author | "Zhong S."xsd:string |
| http://purl.uniprot.org/citations/17074809 | http://purl.uniprot.org/core/author | "Fromm J."xsd:string |
| http://purl.uniprot.org/citations/17074809 | http://purl.uniprot.org/core/author | "Johnson D.L."xsd:string |
| http://purl.uniprot.org/citations/17074809 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17074809 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/17074809 | http://purl.uniprot.org/core/pages | "54-64"xsd:string |
| http://purl.uniprot.org/citations/17074809 | http://purl.uniprot.org/core/title | "TBP is differentially regulated by c-Jun N-terminal kinase 1 (JNK1) and JNK2 through Elk-1, controlling c-Jun expression and cell proliferation."xsd:string |
| http://purl.uniprot.org/citations/17074809 | http://purl.uniprot.org/core/volume | "27"xsd:string |
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