| http://purl.uniprot.org/citations/17076705 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17076705 | http://www.w3.org/2000/01/rdf-schema#comment | "The global epidemic of tuberculosis, fuelled by acquired immune-deficiency syndrome, necessitates the development of a safe and effective vaccine. We have constructed a DeltaRD1DeltapanCD mutant of Mycobacterium tuberculosis (mc(2)6030) that undergoes limited replication and is severely attenuated in immunocompromised mice, yet induces significant protection against tuberculosis in wild-type mice and even in mice that completely lack CD4(+) T cells as a result of targeted disruption of their CD4 genes (CD4(-/-) mice). Ex vivo studies of T cells from mc(2)6030-immunized mice showed that these immune cells responded to protein antigens of M. tuberculosis in a major histocompatibility complex (MHC) class II-restricted manner. Antibody depletion experiments showed that antituberculosis protective responses in the lung were not diminished by removal of CD8(+), T-cell receptor gammadelta (TCR-gammadelta(+)) and NK1.1(+) T cells from vaccinated CD4(-/-) mice before challenge, implying that the observed recall and immune effector functions resulting from vaccination of CD4(-/-) mice with mc(2)6030 were attributable to a population of CD4(-) CD8(-) (double-negative) TCR-alphabeta(+), TCR-gammadelta(-), NK1.1(-) T cells. Transfer of highly enriched double-negative TCR-alphabeta(+) T cells from mc(2)6030-immunized CD4(-/-) mice into naive CD4(-/-) mice resulted in significant protection against an aerosol tuberculosis challenge. Enriched pulmonary double-negative T cells transcribed significantly more interferon-gamma and interleukin-2 mRNA than double-negative T cells from naive mice after a tuberculous challenge. These results confirmed previous findings on the potential for a subset of MHC class II-restricted T cells to develop and function without expression of CD4 and suggest novel vaccination strategies to assist in the control of tuberculosis in human immunodeficiency virus-infected humans who have chronic depletion of their CD4(+) T cells."xsd:string |
| http://purl.uniprot.org/citations/17076705 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1365-2567.2006.02491.x"xsd:string |
| http://purl.uniprot.org/citations/17076705 | http://purl.uniprot.org/core/author | "Chen M."xsd:string |
| http://purl.uniprot.org/citations/17076705 | http://purl.uniprot.org/core/author | "Chen B."xsd:string |
| http://purl.uniprot.org/citations/17076705 | http://purl.uniprot.org/core/author | "Hsu T."xsd:string |
| http://purl.uniprot.org/citations/17076705 | http://purl.uniprot.org/core/author | "Jacobs W.R. Jr."xsd:string |
| http://purl.uniprot.org/citations/17076705 | http://purl.uniprot.org/core/author | "Morris S.L."xsd:string |
| http://purl.uniprot.org/citations/17076705 | http://purl.uniprot.org/core/author | "Russell R.G."xsd:string |
| http://purl.uniprot.org/citations/17076705 | http://purl.uniprot.org/core/author | "Orme I.M."xsd:string |
| http://purl.uniprot.org/citations/17076705 | http://purl.uniprot.org/core/author | "Porcelli S.A."xsd:string |
| http://purl.uniprot.org/citations/17076705 | http://purl.uniprot.org/core/author | "Sambandamurthy V.K."xsd:string |
| http://purl.uniprot.org/citations/17076705 | http://purl.uniprot.org/core/author | "Derrick S.C."xsd:string |
| http://purl.uniprot.org/citations/17076705 | http://purl.uniprot.org/core/author | "Junqueira-Kipnis A.P."xsd:string |
| http://purl.uniprot.org/citations/17076705 | http://purl.uniprot.org/core/author | "Evering T.H."xsd:string |
| http://purl.uniprot.org/citations/17076705 | http://purl.uniprot.org/core/author | "Jalapathy K.V."xsd:string |
| http://purl.uniprot.org/citations/17076705 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17076705 | http://purl.uniprot.org/core/name | "Immunology"xsd:string |
| http://purl.uniprot.org/citations/17076705 | http://purl.uniprot.org/core/pages | "192-206"xsd:string |
| http://purl.uniprot.org/citations/17076705 | http://purl.uniprot.org/core/title | "Characterization of the protective T-cell response generated in CD4-deficient mice by a live attenuated Mycobacterium tuberculosis vaccine."xsd:string |
| http://purl.uniprot.org/citations/17076705 | http://purl.uniprot.org/core/volume | "120"xsd:string |
| http://purl.uniprot.org/citations/17076705 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17076705 |
| http://purl.uniprot.org/citations/17076705 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17076705 |
| http://purl.uniprot.org/uniprot/#_A0A1D8M9B3-mappedCitation-17076705 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17076705 |
| http://purl.uniprot.org/uniprot/#_P70443-mappedCitation-17076705 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17076705 |