| http://purl.uniprot.org/citations/17079289 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17079289 | http://www.w3.org/2000/01/rdf-schema#comment | "The retinoic acid-inducible gene I product (RIG-I) has been identified as a cellular sensor of RNA virus infection resulting in beta interferon (IFN-beta) induction. However, many viruses are known to encode viral products that inhibit IFN-beta production. In the case of influenza A virus, the viral nonstructural protein 1 (NS1) prevents the induction of the IFN-beta promoter by inhibiting the activation of transcription factors, including IRF-3, involved in IFN-beta transcriptional activation. The inhibitory properties of NS1 appear to be due at least in part to its binding to double-stranded RNA (dsRNA), resulting in the sequestration of this viral mediator of RIG-I activation. However, the precise effects of NS1 on the RIG-I-mediated induction of IFN-beta have not been characterized. We now report that the NS1 of influenza A virus interacts with RIG-I and inhibits the RIG-I-mediated induction of IFN-beta. This inhibition was apparent even when a mutant RIG-I that is constitutively activated (in the absence of dsRNA) was used to trigger IFN-beta production. Coexpression of RIG-I, its downstream signaling partner, IPS-1, and NS1 resulted in increased levels of RIG-I and NS1 within an IPS-1-rich, solubilization-resistant fraction after cell lysis. These results suggest that RIG-I, IPS-1, and NS1 become part of the same complex. Consistent with this idea, NS1 was also found to inhibit IFN-beta promoter activation by IPS-1 overexpression. Our results indicate that, in addition to sequestering dsRNA, the NS1 of influenza A virus binds to RIG-I and inhibits downstream activation of IRF-3, preventing the transcriptional induction of IFN-beta."xsd:string |
| http://purl.uniprot.org/citations/17079289 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.01265-06"xsd:string |
| http://purl.uniprot.org/citations/17079289 | http://purl.uniprot.org/core/author | "Gale M. Jr."xsd:string |
| http://purl.uniprot.org/citations/17079289 | http://purl.uniprot.org/core/author | "Loo Y.M."xsd:string |
| http://purl.uniprot.org/citations/17079289 | http://purl.uniprot.org/core/author | "Garcia-Sastre A."xsd:string |
| http://purl.uniprot.org/citations/17079289 | http://purl.uniprot.org/core/author | "Martinez-Sobrido L."xsd:string |
| http://purl.uniprot.org/citations/17079289 | http://purl.uniprot.org/core/author | "Cardenas W.B."xsd:string |
| http://purl.uniprot.org/citations/17079289 | http://purl.uniprot.org/core/author | "Mibayashi M."xsd:string |
| http://purl.uniprot.org/citations/17079289 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17079289 | http://purl.uniprot.org/core/name | "J Virol"xsd:string |
| http://purl.uniprot.org/citations/17079289 | http://purl.uniprot.org/core/pages | "514-524"xsd:string |
| http://purl.uniprot.org/citations/17079289 | http://purl.uniprot.org/core/title | "Inhibition of retinoic acid-inducible gene I-mediated induction of beta interferon by the NS1 protein of influenza A virus."xsd:string |
| http://purl.uniprot.org/citations/17079289 | http://purl.uniprot.org/core/volume | "81"xsd:string |
| http://purl.uniprot.org/citations/17079289 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17079289 |
| http://purl.uniprot.org/citations/17079289 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17079289 |
| http://purl.uniprot.org/uniprot/P03495#attribution-3AEC35FECC9DAD505D8C082062C83F4E | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17079289 |
| http://purl.uniprot.org/uniprot/P03495#attribution-6F559A888019915ACE8B0B1E6A668FED | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17079289 |
| http://purl.uniprot.org/uniprot/Q14653#attribution-6F559A888019915ACE8B0B1E6A668FED | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17079289 |
| http://purl.uniprot.org/uniprot/Q9BYX4#attribution-3AEC35FECC9DAD505D8C082062C83F4E | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17079289 |
| http://purl.uniprot.org/uniprot/O95786#attribution-6F559A888019915ACE8B0B1E6A668FED | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17079289 |
| http://purl.uniprot.org/uniprot/#_A0A7R8GV38-mappedCitation-17079289 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17079289 |
| http://purl.uniprot.org/uniprot/#_B3KN51-mappedCitation-17079289 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17079289 |
| http://purl.uniprot.org/uniprot/#_B4DWT9-mappedCitation-17079289 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17079289 |
| http://purl.uniprot.org/uniprot/#_B3KWW1-mappedCitation-17079289 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17079289 |