| http://purl.uniprot.org/citations/17079736 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17079736 | http://www.w3.org/2000/01/rdf-schema#comment | "Signaling via the epidermal growth factor receptor (EGFR), which has critical roles in development and diseases such as cancer, is regulated by proteolytic shedding of its membrane-tethered ligands. Sheddases for EGFR-ligands are therefore key signaling switches in the EGFR pathway. Here, we determined which ADAMs (a disintegrin and metalloprotease) can shed various EGFR-ligands, and we analyzed the regulation of EGFR-ligand shedding by two commonly used stimuli, phorbol esters and calcium influx. Phorbol esters predominantly activate ADAM17, thereby triggering a burst of shedding of EGFR-ligands from a late secretory pathway compartment. Calcium influx stimulates ADAM10, requiring its cytoplasmic domain. However, calcium influx-stimulated shedding of transforming growth factor alpha and amphiregulin does not require ADAM17, even though ADAM17 is essential for phorbol ester-stimulated shedding of these EGFR-ligands. This study provides new insight into the machinery responsible for EGFR-ligand release and thus EGFR signaling and demonstrates that dysregulated EGFR-ligand shedding may be caused by increased expression of constitutively active sheddases or activation of different sheddases by distinct stimuli."xsd:string |
| http://purl.uniprot.org/citations/17079736 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e06-01-0014"xsd:string |
| http://purl.uniprot.org/citations/17079736 | http://purl.uniprot.org/core/author | "Murphy G."xsd:string |
| http://purl.uniprot.org/citations/17079736 | http://purl.uniprot.org/core/author | "Toyama Y."xsd:string |
| http://purl.uniprot.org/citations/17079736 | http://purl.uniprot.org/core/author | "Yamaguchi T."xsd:string |
| http://purl.uniprot.org/citations/17079736 | http://purl.uniprot.org/core/author | "Reiss K."xsd:string |
| http://purl.uniprot.org/citations/17079736 | http://purl.uniprot.org/core/author | "Saftig P."xsd:string |
| http://purl.uniprot.org/citations/17079736 | http://purl.uniprot.org/core/author | "Le Gall S."xsd:string |
| http://purl.uniprot.org/citations/17079736 | http://purl.uniprot.org/core/author | "Blobel C.P."xsd:string |
| http://purl.uniprot.org/citations/17079736 | http://purl.uniprot.org/core/author | "Hartmann D."xsd:string |
| http://purl.uniprot.org/citations/17079736 | http://purl.uniprot.org/core/author | "Horiuchi K."xsd:string |
| http://purl.uniprot.org/citations/17079736 | http://purl.uniprot.org/core/author | "Schulte M."xsd:string |
| http://purl.uniprot.org/citations/17079736 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17079736 | http://purl.uniprot.org/core/name | "Mol Biol Cell"xsd:string |
| http://purl.uniprot.org/citations/17079736 | http://purl.uniprot.org/core/pages | "176-188"xsd:string |
| http://purl.uniprot.org/citations/17079736 | http://purl.uniprot.org/core/title | "Substrate selectivity of epidermal growth factor-receptor ligand sheddases and their regulation by phorbol esters and calcium influx."xsd:string |
| http://purl.uniprot.org/citations/17079736 | http://purl.uniprot.org/core/volume | "18"xsd:string |
| http://purl.uniprot.org/citations/17079736 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17079736 |
| http://purl.uniprot.org/citations/17079736 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17079736 |
| http://purl.uniprot.org/uniprot/O35598#attribution-729C3AECF5475A65752A6FAE7674CDA3 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17079736 |
| http://purl.uniprot.org/uniprot/#_D3Z1E6-mappedCitation-17079736 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17079736 |
| http://purl.uniprot.org/uniprot/#_A0A338P6F3-mappedCitation-17079736 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17079736 |
| http://purl.uniprot.org/uniprot/#_A0A338P6I8-mappedCitation-17079736 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17079736 |
| http://purl.uniprot.org/uniprot/#_B2RRI1-mappedCitation-17079736 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17079736 |