| http://purl.uniprot.org/citations/17081262 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17081262 | http://www.w3.org/2000/01/rdf-schema#comment | "The CHRM2 gene is thought to be involved in neuronal excitability, synaptic plasticity and feedback regulation of acetylcholine release and has previously been implicated in higher cognitive processing. In a sample of 667 individuals from 304 families, we genotyped three single-nucleotide polymorphisms (SNPs) in the CHRM2 gene on 7q31-35. From all individuals, standardized intelligence measures were available. Using a test of within-family association, which controls for the possible effects of population stratification, a highly significant association was found between the CHRM2 gene and intelligence. The strongest association was between rs324650 and performance IQ (PIQ), where the T allele was associated with an increase of 4.6 PIQ points. In parallel with a large family-based association, we observed an attenuated - although still significant - population-based association, illustrating that population stratification may decrease our chances of detecting allele-trait associations. Such a mechanism has been predicted earlier, and this article is one of the first to empirically show that family-based association methods are not only needed to guard against false positives, but are also invaluable in guarding against false negatives."xsd:string |
| http://purl.uniprot.org/citations/17081262 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1601-183x.2006.00211.x"xsd:string |
| http://purl.uniprot.org/citations/17081262 | http://purl.uniprot.org/core/author | "Boomsma D.I."xsd:string |
| http://purl.uniprot.org/citations/17081262 | http://purl.uniprot.org/core/author | "de Geus E.J."xsd:string |
| http://purl.uniprot.org/citations/17081262 | http://purl.uniprot.org/core/author | "Posthuma D."xsd:string |
| http://purl.uniprot.org/citations/17081262 | http://purl.uniprot.org/core/author | "Heutink P."xsd:string |
| http://purl.uniprot.org/citations/17081262 | http://purl.uniprot.org/core/author | "Gosso M.F."xsd:string |
| http://purl.uniprot.org/citations/17081262 | http://purl.uniprot.org/core/author | "Polderman J.C."xsd:string |
| http://purl.uniprot.org/citations/17081262 | http://purl.uniprot.org/core/author | "van Belzen M."xsd:string |
| http://purl.uniprot.org/citations/17081262 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17081262 | http://purl.uniprot.org/core/name | "Genes Brain Behav"xsd:string |
| http://purl.uniprot.org/citations/17081262 | http://purl.uniprot.org/core/pages | "577-584"xsd:string |
| http://purl.uniprot.org/citations/17081262 | http://purl.uniprot.org/core/title | "Association between the CHRM2 gene and intelligence in a sample of 304 Dutch families."xsd:string |
| http://purl.uniprot.org/citations/17081262 | http://purl.uniprot.org/core/volume | "5"xsd:string |
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