| http://purl.uniprot.org/citations/17082180 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17082180 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17082180 | http://www.w3.org/2000/01/rdf-schema#comment | "Fanconi anemia (FA) is a rare autosomal recessive and X-linked chromosomal instability disorder. At least eight FA proteins (FANCA, B, C, E, F, G, L, and M) form a nuclear core complex required for monoubiquitination of a downstream protein, FANCD2. The human FANCF protein reportedly functions as a molecular adaptor within the FA nuclear complex, bridging between the subcomplexes A:G and C:E. Our x-ray crystallographic studies of the C-terminal domain of FANCF reveal a helical repeat structure similar to the Cand1 regulator of the Cul1-Rbx1-Skp1-Fbox(Skp2) ubiquitin ligase complex. Two C-terminal loops of FANCF are essential for monoubiquitination of FANCD2 and normal cellular resistance to the DNA cross-linking agent mitomycin C. FANCF mutants bearing amino acid substitutions in this C-terminal surface fail to interact with other components of the FA complex, indicating that this surface is critical for the proper assembly of the FA core complex."xsd:string |
| http://purl.uniprot.org/citations/17082180 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m608356200"xsd:string |
| http://purl.uniprot.org/citations/17082180 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m608356200"xsd:string |
| http://purl.uniprot.org/citations/17082180 | http://purl.uniprot.org/core/author | "D'Andrea A.D."xsd:string |
| http://purl.uniprot.org/citations/17082180 | http://purl.uniprot.org/core/author | "D'Andrea A.D."xsd:string |
| http://purl.uniprot.org/citations/17082180 | http://purl.uniprot.org/core/author | "Ellenberger T."xsd:string |
| http://purl.uniprot.org/citations/17082180 | http://purl.uniprot.org/core/author | "Ellenberger T."xsd:string |
| http://purl.uniprot.org/citations/17082180 | http://purl.uniprot.org/core/author | "Kowal P."xsd:string |
| http://purl.uniprot.org/citations/17082180 | http://purl.uniprot.org/core/author | "Kowal P."xsd:string |
| http://purl.uniprot.org/citations/17082180 | http://purl.uniprot.org/core/author | "Stuckert P."xsd:string |
| http://purl.uniprot.org/citations/17082180 | http://purl.uniprot.org/core/author | "Stuckert P."xsd:string |
| http://purl.uniprot.org/citations/17082180 | http://purl.uniprot.org/core/author | "Gurtan A.M."xsd:string |
| http://purl.uniprot.org/citations/17082180 | http://purl.uniprot.org/core/author | "Gurtan A.M."xsd:string |
| http://purl.uniprot.org/citations/17082180 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17082180 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17082180 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/17082180 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/17082180 | http://purl.uniprot.org/core/pages | "2047-2055"xsd:string |
| http://purl.uniprot.org/citations/17082180 | http://purl.uniprot.org/core/pages | "2047-2055"xsd:string |
| http://purl.uniprot.org/citations/17082180 | http://purl.uniprot.org/core/title | "Structural determinants of human FANCF protein that function in the assembly of a DNA damage signaling complex."xsd:string |
| http://purl.uniprot.org/citations/17082180 | http://purl.uniprot.org/core/title | "Structural determinants of human FANCF protein that function in the assembly of a DNA damage signaling complex."xsd:string |
| http://purl.uniprot.org/citations/17082180 | http://purl.uniprot.org/core/volume | "282"xsd:string |
| http://purl.uniprot.org/citations/17082180 | http://purl.uniprot.org/core/volume | "282"xsd:string |