| http://purl.uniprot.org/citations/17082189 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17082189 | http://www.w3.org/2000/01/rdf-schema#comment | "The eukaryotic Y-box-binding protein-1 (YB-1) is involved in the transcriptional and translational control of many biological processes, including cell proliferation. In clinical studies, the cellular level of YB-1 closely correlates with tumor growth and prognosis. To understand the role of YB-1 in vivo, especially in the developmental process, we generated YB-1 knock-out mice, which are embryonic lethal and exhibit exencephaly associated with abnormal patterns of cell proliferation within the neuroepithelium. beta-Actin expression and F-actin formation were reduced in the YB-1 null embryo and YB-1(-/-) mouse embryonic fibroblasts, suggesting that the neural tube defect is caused by abnormal cell morphology and actin assembly within the neuroepithelium. Fibroblasts derived from YB-1(-/-) embryos demonstrated reduced growth and cell density. A colony formation assay showed that YB-1(-/-) mouse embryonic fibroblasts failed to undergo morphological transformation and remained contact-inhibited in culture. These results demonstrate that YB-1 is involved in early mouse development, including neural tube closure and cell proliferation."xsd:string |
| http://purl.uniprot.org/citations/17082189 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m605948200"xsd:string |
| http://purl.uniprot.org/citations/17082189 | http://purl.uniprot.org/core/author | "Kohno K."xsd:string |
| http://purl.uniprot.org/citations/17082189 | http://purl.uniprot.org/core/author | "Fukuda T."xsd:string |
| http://purl.uniprot.org/citations/17082189 | http://purl.uniprot.org/core/author | "Nakamura T."xsd:string |
| http://purl.uniprot.org/citations/17082189 | http://purl.uniprot.org/core/author | "Shimada T."xsd:string |
| http://purl.uniprot.org/citations/17082189 | http://purl.uniprot.org/core/author | "Tsuzuki T."xsd:string |
| http://purl.uniprot.org/citations/17082189 | http://purl.uniprot.org/core/author | "Uchiumi T."xsd:string |
| http://purl.uniprot.org/citations/17082189 | http://purl.uniprot.org/core/author | "Shibahara K."xsd:string |
| http://purl.uniprot.org/citations/17082189 | http://purl.uniprot.org/core/author | "Kuwano M."xsd:string |
| http://purl.uniprot.org/citations/17082189 | http://purl.uniprot.org/core/author | "Izumi H."xsd:string |
| http://purl.uniprot.org/citations/17082189 | http://purl.uniprot.org/core/author | "Sasaguri T."xsd:string |
| http://purl.uniprot.org/citations/17082189 | http://purl.uniprot.org/core/author | "Fotovati A."xsd:string |
| http://purl.uniprot.org/citations/17082189 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17082189 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/17082189 | http://purl.uniprot.org/core/pages | "40440-40449"xsd:string |
| http://purl.uniprot.org/citations/17082189 | http://purl.uniprot.org/core/title | "YB-1 is important for an early stage embryonic development: neural tube formation and cell proliferation."xsd:string |
| http://purl.uniprot.org/citations/17082189 | http://purl.uniprot.org/core/volume | "281"xsd:string |
| http://purl.uniprot.org/citations/17082189 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17082189 |
| http://purl.uniprot.org/citations/17082189 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17082189 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JG98-mappedCitation-17082189 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17082189 |
| http://purl.uniprot.org/uniprot/#_D3Z783-mappedCitation-17082189 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17082189 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGT5-mappedCitation-17082189 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17082189 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JH04-mappedCitation-17082189 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17082189 |