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http://purl.uniprot.org/citations/17082457http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/17082457http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/17082457http://www.w3.org/2000/01/rdf-schema#comment"Guanosine triphosphatases of the Rab family are key regulators of membrane trafficking, with Rab11 playing a specific role in membrane recycling. We identified a mammalian protein, protrudin, that promoted neurite formation through interaction with the guanosine diphosphate (GDP)-bound form of Rab11. Phosphorylation of protrudin by extracellular signal-regulated kinase (ERK) in response to nerve growth factor promoted protrudin association with Rab11-GDP. Down-regulation of protrudin by RNA interference induced membrane extension in all directions and inhibited neurite formation. Thus, protrudin regulates Rab11-dependent membrane recycling to promote the directional membrane trafficking required for neurite formation."xsd:string
http://purl.uniprot.org/citations/17082457http://purl.org/dc/terms/identifier"doi:10.1126/science.1134027"xsd:string
http://purl.uniprot.org/citations/17082457http://purl.org/dc/terms/identifier"doi:10.1126/science.1134027"xsd:string
http://purl.uniprot.org/citations/17082457http://purl.uniprot.org/core/author"Nakayama K.I."xsd:string
http://purl.uniprot.org/citations/17082457http://purl.uniprot.org/core/author"Nakayama K.I."xsd:string
http://purl.uniprot.org/citations/17082457http://purl.uniprot.org/core/author"Shirane M."xsd:string
http://purl.uniprot.org/citations/17082457http://purl.uniprot.org/core/author"Shirane M."xsd:string
http://purl.uniprot.org/citations/17082457http://purl.uniprot.org/core/date"2006"xsd:gYear
http://purl.uniprot.org/citations/17082457http://purl.uniprot.org/core/date"2006"xsd:gYear
http://purl.uniprot.org/citations/17082457http://purl.uniprot.org/core/name"Science"xsd:string
http://purl.uniprot.org/citations/17082457http://purl.uniprot.org/core/name"Science"xsd:string
http://purl.uniprot.org/citations/17082457http://purl.uniprot.org/core/pages"818-821"xsd:string
http://purl.uniprot.org/citations/17082457http://purl.uniprot.org/core/pages"818-821"xsd:string
http://purl.uniprot.org/citations/17082457http://purl.uniprot.org/core/title"Protrudin induces neurite formation by directional membrane trafficking."xsd:string
http://purl.uniprot.org/citations/17082457http://purl.uniprot.org/core/title"Protrudin induces neurite formation by directional membrane trafficking."xsd:string
http://purl.uniprot.org/citations/17082457http://purl.uniprot.org/core/volume"314"xsd:string
http://purl.uniprot.org/citations/17082457http://purl.uniprot.org/core/volume"314"xsd:string
http://purl.uniprot.org/citations/17082457http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/17082457
http://purl.uniprot.org/citations/17082457http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/17082457
http://purl.uniprot.org/citations/17082457http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/17082457
http://purl.uniprot.org/citations/17082457http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/17082457
http://purl.uniprot.org/uniprot/P62491http://purl.uniprot.org/core/citationhttp://purl.uniprot.org/citations/17082457
http://purl.uniprot.org/uniprot/P62494http://purl.uniprot.org/core/citationhttp://purl.uniprot.org/citations/17082457