| http://purl.uniprot.org/citations/17082571 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17082571 | http://www.w3.org/2000/01/rdf-schema#comment | "CD4+CD25+Foxp3+ regulatory T cells (Tregs) contribute to the maintenance of peripheral tolerance by inhibiting the expansion and function of conventional T cells. Treg development and homeostasis are regulated by the Ag receptor, costimulatory receptors such as CD28 and CTLA-4, and cytokines such as IL-2, IL-10, and TGF-beta. Here we show that the proportions of Tregs in the spleen and lymph nodes of mice with inactive p110delta PI3K (p110deltaD910A/D910A) are reduced despite enhanced Treg selection in the thymus. p110deltaD910A/D910A CD4+CD25+Foxp3+ Tregs showed attenuated suppressor function in vitro and failed to secrete IL-10. In adoptive transfer experiments, p110deltaD910A/D910A T cells failed to protect against experimental colitis. The identification of p110delta as an intracellular signaling protein that regulates the activity of CD4+CD25+Foxp3+ Tregs may facilitate the further elucidation of the molecular mechanisms responsible for Treg-mediated suppression."xsd:string |
| http://purl.uniprot.org/citations/17082571 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.177.10.6598"xsd:string |
| http://purl.uniprot.org/citations/17082571 | http://purl.uniprot.org/core/author | "Leung E."xsd:string |
| http://purl.uniprot.org/citations/17082571 | http://purl.uniprot.org/core/author | "Walker L.S."xsd:string |
| http://purl.uniprot.org/citations/17082571 | http://purl.uniprot.org/core/author | "Patton D.T."xsd:string |
| http://purl.uniprot.org/citations/17082571 | http://purl.uniprot.org/core/author | "Vanhaesebroeck B."xsd:string |
| http://purl.uniprot.org/citations/17082571 | http://purl.uniprot.org/core/author | "Okkenhaug K."xsd:string |
| http://purl.uniprot.org/citations/17082571 | http://purl.uniprot.org/core/author | "Sancho S."xsd:string |
| http://purl.uniprot.org/citations/17082571 | http://purl.uniprot.org/core/author | "Garden O.A."xsd:string |
| http://purl.uniprot.org/citations/17082571 | http://purl.uniprot.org/core/author | "Monk C.R."xsd:string |
| http://purl.uniprot.org/citations/17082571 | http://purl.uniprot.org/core/author | "Clough L.E."xsd:string |
| http://purl.uniprot.org/citations/17082571 | http://purl.uniprot.org/core/author | "Rowan W.C."xsd:string |
| http://purl.uniprot.org/citations/17082571 | http://purl.uniprot.org/core/author | "Pearce W.P."xsd:string |
| http://purl.uniprot.org/citations/17082571 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17082571 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/17082571 | http://purl.uniprot.org/core/pages | "6598-6602"xsd:string |
| http://purl.uniprot.org/citations/17082571 | http://purl.uniprot.org/core/title | "Cutting edge: the phosphoinositide 3-kinase p110 delta is critical for the function of CD4+CD25+Foxp3+ regulatory T cells."xsd:string |
| http://purl.uniprot.org/citations/17082571 | http://purl.uniprot.org/core/volume | "177"xsd:string |
| http://purl.uniprot.org/citations/17082571 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17082571 |
| http://purl.uniprot.org/citations/17082571 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17082571 |
| http://purl.uniprot.org/uniprot/#_B0QZL5-mappedCitation-17082571 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17082571 |
| http://purl.uniprot.org/uniprot/#_B1AS24-mappedCitation-17082571 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17082571 |
| http://purl.uniprot.org/uniprot/#_B1AS25-mappedCitation-17082571 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17082571 |
| http://purl.uniprot.org/uniprot/#_B1AS26-mappedCitation-17082571 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17082571 |