| http://purl.uniprot.org/citations/17082577 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17082577 | http://www.w3.org/2000/01/rdf-schema#comment | "Although invariant NKT (iNKT) cells participate in many aspects of immune responses, the molecular mechanisms regulating their development, maturation, and activation are still poorly understood. GATA-3 is a T cell-specific transcription factor that is also expressed in iNKT cells. The critical role of GATA-3 in conventional alphabeta T cells has been well documented, but whether GATA-3 also regulates the development and function of iNKT cells is unknown. In the present study, we report that deficiency of GATA-3 results in cell-intrinsic defects in the thymic development and peripheral maturation of murine iNKT cells. In addition, GATA-3 is also required for survival, activation, and effector functions of this unique population of T cells. Our data also reveal a previously unidentified peripheral maturation step that is GATA-3 dependent."xsd:string |
| http://purl.uniprot.org/citations/17082577 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.177.10.6650"xsd:string |
| http://purl.uniprot.org/citations/17082577 | http://purl.uniprot.org/core/author | "Besra G.S."xsd:string |
| http://purl.uniprot.org/citations/17082577 | http://purl.uniprot.org/core/author | "Kim P.J."xsd:string |
| http://purl.uniprot.org/citations/17082577 | http://purl.uniprot.org/core/author | "Brigl M."xsd:string |
| http://purl.uniprot.org/citations/17082577 | http://purl.uniprot.org/core/author | "Ho I.C."xsd:string |
| http://purl.uniprot.org/citations/17082577 | http://purl.uniprot.org/core/author | "Pai S.Y."xsd:string |
| http://purl.uniprot.org/citations/17082577 | http://purl.uniprot.org/core/author | "Gumperz J."xsd:string |
| http://purl.uniprot.org/citations/17082577 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17082577 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/17082577 | http://purl.uniprot.org/core/pages | "6650-6659"xsd:string |
| http://purl.uniprot.org/citations/17082577 | http://purl.uniprot.org/core/title | "GATA-3 regulates the development and function of invariant NKT cells."xsd:string |
| http://purl.uniprot.org/citations/17082577 | http://purl.uniprot.org/core/volume | "177"xsd:string |
| http://purl.uniprot.org/citations/17082577 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17082577 |
| http://purl.uniprot.org/citations/17082577 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17082577 |
| http://purl.uniprot.org/uniprot/P48036#attribution-53FA1593CE7D0F3A050706AE435FCBAD | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17082577 |
| http://purl.uniprot.org/uniprot/P25918#attribution-53FA1593CE7D0F3A050706AE435FCBAD | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17082577 |
| http://purl.uniprot.org/uniprot/P06332#attribution-53FA1593CE7D0F3A050706AE435FCBAD | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17082577 |
| http://purl.uniprot.org/uniprot/P27548#attribution-53FA1593CE7D0F3A050706AE435FCBAD | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17082577 |
| http://purl.uniprot.org/uniprot/P37217#attribution-53FA1593CE7D0F3A050706AE435FCBAD | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17082577 |
| http://purl.uniprot.org/uniprot/P15379#attribution-53FA1593CE7D0F3A050706AE435FCBAD | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17082577 |
| http://purl.uniprot.org/uniprot/P11609#attribution-53FA1593CE7D0F3A050706AE435FCBAD | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17082577 |
| http://purl.uniprot.org/uniprot/P01731#attribution-53FA1593CE7D0F3A050706AE435FCBAD | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17082577 |
| http://purl.uniprot.org/uniprot/P23772#attribution-D8A14202FC98B126D1644EAD1654B0A5 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17082577 |