| http://purl.uniprot.org/citations/17082579 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17082579 | http://www.w3.org/2000/01/rdf-schema#comment | "By virtue of their ability to express a plethora of biologically highly active mediators, mast cells (MC) are involved in both adaptive and innate immune responses. MC-derived Th2-type cytokines are thought to act as local amplifiers of Th2 reactions, including chronic inflammatory disorders such as allergic asthma, whereas MC-derived TNF-alpha is a critical initiator of antimicrobial defense. In this study, we demonstrate that the transcription factors NFATc1 and NFATc2 are part of a MC-specific signaling network that regulates the expression of TNF-alpha and IL-13, whereas NFATc3 is dispensable. Primary murine bone marrow-derived MC from NFATc2(-/-) mice, activated by either ionomycin or IgE/Ag cross-link, display a strong reduction in the production of these cytokines, compared with bone marrow-derived MC from wild-type mice. Detailed analyses of TNF-alpha and IL-13 expression using small interfering RNA-mediated knockdown reveals that both NFATc2 and NFATc1 are able to drive the expression of these cytokines, whereas neither degranulation nor the expression of IL-6 depends on NFAT activity. These results support the view that high NFAT activity is necessary for TNF-alpha and IL-13 promoter induction in MC, irrespective of whether NFATc2 or NFATc1 or a combination of both is present."xsd:string |
| http://purl.uniprot.org/citations/17082579 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.177.10.6667"xsd:string |
| http://purl.uniprot.org/citations/17082579 | http://purl.uniprot.org/core/author | "Becker M."xsd:string |
| http://purl.uniprot.org/citations/17082579 | http://purl.uniprot.org/core/author | "Klein M."xsd:string |
| http://purl.uniprot.org/citations/17082579 | http://purl.uniprot.org/core/author | "Schmitt E."xsd:string |
| http://purl.uniprot.org/citations/17082579 | http://purl.uniprot.org/core/author | "Stassen M."xsd:string |
| http://purl.uniprot.org/citations/17082579 | http://purl.uniprot.org/core/author | "Klein-Hessling S."xsd:string |
| http://purl.uniprot.org/citations/17082579 | http://purl.uniprot.org/core/author | "Serfling E."xsd:string |
| http://purl.uniprot.org/citations/17082579 | http://purl.uniprot.org/core/author | "Bopp T."xsd:string |
| http://purl.uniprot.org/citations/17082579 | http://purl.uniprot.org/core/author | "Schild H."xsd:string |
| http://purl.uniprot.org/citations/17082579 | http://purl.uniprot.org/core/author | "Taube C."xsd:string |
| http://purl.uniprot.org/citations/17082579 | http://purl.uniprot.org/core/author | "Heib V."xsd:string |
| http://purl.uniprot.org/citations/17082579 | http://purl.uniprot.org/core/author | "Tertilt C."xsd:string |
| http://purl.uniprot.org/citations/17082579 | http://purl.uniprot.org/core/author | "Palmetshofer A."xsd:string |
| http://purl.uniprot.org/citations/17082579 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17082579 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/17082579 | http://purl.uniprot.org/core/pages | "6667-6674"xsd:string |
| http://purl.uniprot.org/citations/17082579 | http://purl.uniprot.org/core/title | "Specific and redundant roles for NFAT transcription factors in the expression of mast cell-derived cytokines."xsd:string |
| http://purl.uniprot.org/citations/17082579 | http://purl.uniprot.org/core/volume | "177"xsd:string |
| http://purl.uniprot.org/citations/17082579 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17082579 |
| http://purl.uniprot.org/citations/17082579 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17082579 |
| http://purl.uniprot.org/uniprot/#_A2AQC8-mappedCitation-17082579 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17082579 |
| http://purl.uniprot.org/uniprot/#_B5B2N2-mappedCitation-17082579 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17082579 |
| http://purl.uniprot.org/uniprot/#_B5B2N4-mappedCitation-17082579 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17082579 |