| http://purl.uniprot.org/citations/17082597 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17082597 | http://www.w3.org/2000/01/rdf-schema#comment | "Ab targeting of TIRC7 has been shown previously to inhibit T cell proliferation and Th1 lymphocyte-associated cytokine production. In this study, we demonstrate that Ab targeting of TIRC7 induces early cell surface expression of CTLA-4. The majority of stimulated CD4+ and CD8+ human T cells coexpress CTLA-4 and TIRC7. Similar to CTLA-4, TIRC7 rapidly accumulates at the site of Ag adhesion upon T cell activation. TIRC7 seems to colocalize with CTLA-4 in human T cells, and both molecules are associated with clathrin-coated vesicles, indicating they share intracellular transport systems. Moreover, Ab targeting of TIRC7 results in an early activation of CTLA-4 transcription. The inhibition of cell proliferation mediated by TIRC7 is dependent on CTLA-4 expression because the TIRC7-mediated inhibitory effects on cell proliferation and cytokine expression are abolished by Ab blockade of CTLA-4. Splenocytes obtained from CTLA-4-deficient mice are not responsive to TIRC7 Ab targeting. Thus, TIRC7 acts as an upstream regulatory molecule of CTLA-4 expression."xsd:string |
| http://purl.uniprot.org/citations/17082597 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.177.10.6833"xsd:string |
| http://purl.uniprot.org/citations/17082597 | http://purl.uniprot.org/core/author | "Schulze A."xsd:string |
| http://purl.uniprot.org/citations/17082597 | http://purl.uniprot.org/core/author | "Walter S."xsd:string |
| http://purl.uniprot.org/citations/17082597 | http://purl.uniprot.org/core/author | "Wiesner B."xsd:string |
| http://purl.uniprot.org/citations/17082597 | http://purl.uniprot.org/core/author | "Blumberg R.S."xsd:string |
| http://purl.uniprot.org/citations/17082597 | http://purl.uniprot.org/core/author | "Veh R.W."xsd:string |
| http://purl.uniprot.org/citations/17082597 | http://purl.uniprot.org/core/author | "Schulein R."xsd:string |
| http://purl.uniprot.org/citations/17082597 | http://purl.uniprot.org/core/author | "Heinemann T."xsd:string |
| http://purl.uniprot.org/citations/17082597 | http://purl.uniprot.org/core/author | "Utku N."xsd:string |
| http://purl.uniprot.org/citations/17082597 | http://purl.uniprot.org/core/author | "Winter M."xsd:string |
| http://purl.uniprot.org/citations/17082597 | http://purl.uniprot.org/core/author | "Sabat R."xsd:string |
| http://purl.uniprot.org/citations/17082597 | http://purl.uniprot.org/core/author | "Volk H.D."xsd:string |
| http://purl.uniprot.org/citations/17082597 | http://purl.uniprot.org/core/author | "Lohler J."xsd:string |
| http://purl.uniprot.org/citations/17082597 | http://purl.uniprot.org/core/author | "Bulwin G.C."xsd:string |
| http://purl.uniprot.org/citations/17082597 | http://purl.uniprot.org/core/author | "Schlawinsky M."xsd:string |
| http://purl.uniprot.org/citations/17082597 | http://purl.uniprot.org/core/author | "Bugge V."xsd:string |
| http://purl.uniprot.org/citations/17082597 | http://purl.uniprot.org/core/author | "Lohan A."xsd:string |
| http://purl.uniprot.org/citations/17082597 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17082597 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/17082597 | http://purl.uniprot.org/core/pages | "6833-6841"xsd:string |
| http://purl.uniprot.org/citations/17082597 | http://purl.uniprot.org/core/title | "TIRC7 inhibits T cell proliferation by modulation of CTLA-4 expression."xsd:string |
| http://purl.uniprot.org/citations/17082597 | http://purl.uniprot.org/core/volume | "177"xsd:string |
| http://purl.uniprot.org/citations/17082597 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17082597 |