| http://purl.uniprot.org/citations/17082625 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17082625 | http://www.w3.org/2000/01/rdf-schema#comment | "Although it is known that IFN-gamma-secreting T cells are critical for control of Mycobacterium tuberculosis infection, the contribution of IFN-gamma produced by NK cells to host resistance to the pathogen is less well understood. By using T cell-deficient RAG(-/-) mice, we showed that M. tuberculosis stimulates NK cell-dependent IFN-gamma production in naive splenic cultures and in lungs of infected animals. More importantly, common cytokine receptor gamma-chain(-/-)RAG(-/-) animals deficient in NK cells, p40(-/-)RAG(-/-), or anti-IFN-gamma mAb-treated RAG(-/-) mice displayed significantly increased susceptibility to M. tuberculosis infection compared with untreated NK-sufficient RAG(-/-) controls. Studies comparing IL-12 p40- and p35-deficient RAG(-/-) mice indicated that IL-12 plays a more critical role in the induction of IFN-gamma-mediated antimycobacterial effector functions than IL-23 or other p40-containing IL-12 family members. The increased susceptibility of IL-12-deficient or anti-IFN-gamma mAb-treated RAG(-/-) mice was associated not only with elevated bacterial loads, but also with the development of granulocyte-enriched foci in lungs. This tissue response correlated with increased expression of the granulocyte chemotactic chemokines KC and MIP-2 in NK as well as other leukocyte populations. Interestingly, depletion of granulocytes further increased bacterial burdens and exacerbated pulmonary pathology in these animals, revealing a compensatory function for neutrophils in the absence of IFN-gamma. The above observations indicate that NK cell-derived IFN-gamma differentially regulates T-independent resistance and granulocyte function in M. tuberculosis infection and suggest that this response could serve as an important barrier in AIDS patients or other individuals with compromised CD4+ T cell function."xsd:string |
| http://purl.uniprot.org/citations/17082625 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.177.10.7086"xsd:string |
| http://purl.uniprot.org/citations/17082625 | http://purl.uniprot.org/core/author | "Sher A."xsd:string |
| http://purl.uniprot.org/citations/17082625 | http://purl.uniprot.org/core/author | "Cheever A."xsd:string |
| http://purl.uniprot.org/citations/17082625 | http://purl.uniprot.org/core/author | "Wynn T.A."xsd:string |
| http://purl.uniprot.org/citations/17082625 | http://purl.uniprot.org/core/author | "Feng C.G."xsd:string |
| http://purl.uniprot.org/citations/17082625 | http://purl.uniprot.org/core/author | "Young H.A."xsd:string |
| http://purl.uniprot.org/citations/17082625 | http://purl.uniprot.org/core/author | "Hieny S."xsd:string |
| http://purl.uniprot.org/citations/17082625 | http://purl.uniprot.org/core/author | "Rothfuchs A.G."xsd:string |
| http://purl.uniprot.org/citations/17082625 | http://purl.uniprot.org/core/author | "Kaviratne M."xsd:string |
| http://purl.uniprot.org/citations/17082625 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17082625 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/17082625 | http://purl.uniprot.org/core/pages | "7086-7093"xsd:string |
| http://purl.uniprot.org/citations/17082625 | http://purl.uniprot.org/core/title | "NK cell-derived IFN-gamma differentially regulates innate resistance and neutrophil response in T cell-deficient hosts infected with Mycobacterium tuberculosis."xsd:string |
| http://purl.uniprot.org/citations/17082625 | http://purl.uniprot.org/core/volume | "177"xsd:string |
| http://purl.uniprot.org/citations/17082625 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17082625 |
| http://purl.uniprot.org/citations/17082625 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17082625 |
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| http://purl.uniprot.org/uniprot/#_P34902-mappedCitation-17082625 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17082625 |