| http://purl.uniprot.org/citations/17082665 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17082665 | http://www.w3.org/2000/01/rdf-schema#comment | "Wiskott-Aldrich syndrome (WAS) protein (WASP) plays a key role in TCR-mediated activation and immunological synapse formation. However, the effects of WASP deficiency on effector functions of human CD4+ and CD8+ T cells remain to be determined. In this study, we report that TCR/CD28-driven proliferation and secretion of IL-2, IFN-gamma, and TNF-alpha are strongly reduced in CD8+ T cells from WAS patients, compared with healthy donor CD8+ T cells. Furthermore, WAS CD4+ T cells secrete low levels of IL-2 and fail to produce IFN-gamma and TNF-alpha, while the production of IL-4, IL-5, and IL-10 is only minimally affected. Defective IL-2 and IFN-gamma production persists after culture of naive WAS CD4+ T cells in Th1-polarizing conditions. The defect in Th1 cytokine production by WAS CD4+ and CD8+ T cells is also present at the transcriptional level, as shown by reduced IL-2 and IFN-gamma mRNA transcripts after TCR/CD28 triggering. The reduced transcription of Th1 cytokine genes in WAS CD4+ T cells is associated with a defective induction of T-bet mRNA and a reduction in the early nuclear recruitment of NFAT-1, while the defective activation of WAS CD8+ T cells correlates with reduced nuclear recruitment of both NFAT-1 and NFAT-2. Together, our data indicate that WASP regulates the transcriptional activation of T cells and is required specifically for Th1 cytokine production."xsd:string |
| http://purl.uniprot.org/citations/17082665 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.177.10.7451"xsd:string |
| http://purl.uniprot.org/citations/17082665 | http://purl.uniprot.org/core/author | "Notarangelo L.D."xsd:string |
| http://purl.uniprot.org/citations/17082665 | http://purl.uniprot.org/core/author | "Aiuti A."xsd:string |
| http://purl.uniprot.org/citations/17082665 | http://purl.uniprot.org/core/author | "Martino S."xsd:string |
| http://purl.uniprot.org/citations/17082665 | http://purl.uniprot.org/core/author | "Roncarolo M.G."xsd:string |
| http://purl.uniprot.org/citations/17082665 | http://purl.uniprot.org/core/author | "Scaramuzza S."xsd:string |
| http://purl.uniprot.org/citations/17082665 | http://purl.uniprot.org/core/author | "Dupre L."xsd:string |
| http://purl.uniprot.org/citations/17082665 | http://purl.uniprot.org/core/author | "Sitia G."xsd:string |
| http://purl.uniprot.org/citations/17082665 | http://purl.uniprot.org/core/author | "Guidotti L.G."xsd:string |
| http://purl.uniprot.org/citations/17082665 | http://purl.uniprot.org/core/author | "Marangoni F."xsd:string |
| http://purl.uniprot.org/citations/17082665 | http://purl.uniprot.org/core/author | "Saracco P."xsd:string |
| http://purl.uniprot.org/citations/17082665 | http://purl.uniprot.org/core/author | "Trifari S."xsd:string |
| http://purl.uniprot.org/citations/17082665 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17082665 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/17082665 | http://purl.uniprot.org/core/pages | "7451-7461"xsd:string |
| http://purl.uniprot.org/citations/17082665 | http://purl.uniprot.org/core/title | "Defective Th1 cytokine gene transcription in CD4+ and CD8+ T cells from Wiskott-Aldrich syndrome patients."xsd:string |
| http://purl.uniprot.org/citations/17082665 | http://purl.uniprot.org/core/volume | "177"xsd:string |
| http://purl.uniprot.org/citations/17082665 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17082665 |
| http://purl.uniprot.org/citations/17082665 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17082665 |
| http://purl.uniprot.org/uniprot/#_A8K9C6-mappedCitation-17082665 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17082665 |
| http://purl.uniprot.org/uniprot/#_B4DER8-mappedCitation-17082665 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17082665 |
| http://purl.uniprot.org/uniprot/#_B5B2P4-mappedCitation-17082665 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17082665 |
| http://purl.uniprot.org/uniprot/#_B7Z8Y1-mappedCitation-17082665 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17082665 |