| http://purl.uniprot.org/citations/17085452 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17085452 | http://www.w3.org/2000/01/rdf-schema#comment | "Endochondral ossification is recapitulated during bone morphogenetic protein (BMP)-induced ectopic bone formation. Although BMP and beta-catenin have been investigated in bone development and in mesenchymal cells, how they interact in this process is not clear. We implanted recombinant BMP-2 into the muscle of mice to investigate the effect of beta-catenin signaling on BMP-induced in vivo endochondral bone formation. BMP-2 induced expression of several Wnt ligands and their receptors and also activated beta-catenin-mediated T cell factor-dependent transcriptional activity. An adenovirus expressing Dickkopf-1 (Dkk-1, an inhibitor of canonical Wnt pathway) inhibited beta-catenin signaling and endochondral bone formation. Interestingly, Dkk-1 inhibited both chondrogenesis and osteogenesis. Likewise, mice expressing conditional beta-catenin null alleles also displayed an inhibition of BMP-induced chondrogenesis and osteogenesis. This is in contrast to studies of embryonic skeletogenesis, which demonstrate that beta-catenin is required for osteogenesis but is dispensable for chondrogenesis. These findings suggest that embryonic development pathways are not always recapitulated during post-natal regenerative processes, and the biochemical pathways utilized to regulate cell differentiation may be different. During in vivo ectopic bone formation, BMP-2 induces beta-catenin-mediated signaling through Wnt ligands, and beta-catenin is required for both chondrogenesis and osteogenesis."xsd:string |
| http://purl.uniprot.org/citations/17085452 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m602700200"xsd:string |
| http://purl.uniprot.org/citations/17085452 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/17085452 | http://purl.uniprot.org/core/author | "Lin A.C."xsd:string |
| http://purl.uniprot.org/citations/17085452 | http://purl.uniprot.org/core/author | "Alman B.A."xsd:string |
| http://purl.uniprot.org/citations/17085452 | http://purl.uniprot.org/core/author | "Nadesan P."xsd:string |
| http://purl.uniprot.org/citations/17085452 | http://purl.uniprot.org/core/author | "Youn A."xsd:string |
| http://purl.uniprot.org/citations/17085452 | http://purl.uniprot.org/core/author | "Chow E.C."xsd:string |
| http://purl.uniprot.org/citations/17085452 | http://purl.uniprot.org/core/author | "Whetstone H.C."xsd:string |
| http://purl.uniprot.org/citations/17085452 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17085452 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/17085452 | http://purl.uniprot.org/core/pages | "526-533"xsd:string |
| http://purl.uniprot.org/citations/17085452 | http://purl.uniprot.org/core/title | "Beta-catenin signaling pathway is crucial for bone morphogenetic protein 2 to induce new bone formation."xsd:string |
| http://purl.uniprot.org/citations/17085452 | http://purl.uniprot.org/core/volume | "282"xsd:string |
| http://purl.uniprot.org/citations/17085452 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17085452 |
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