| http://purl.uniprot.org/citations/17088211 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17088211 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17088211 | http://www.w3.org/2000/01/rdf-schema#comment | "Arc/Arg3.1 is an immediate-early gene whose mRNA is rapidly transcribed and targeted to dendrites of neurons as they engage in information processing and storage. Moreover, Arc/Arg3.1 is known to be required for durable forms of synaptic plasticity and learning. Despite these intriguing links to plasticity, Arc/Arg3.1's molecular function remains enigmatic. Here, we demonstrate that Arc/Arg3.1 protein interacts with dynamin and specific isoforms of endophilin to enhance receptor endocytosis. Arc/Arg3.1 selectively modulates trafficking of AMPA-type glutamate receptors (AMPARs) in neurons by accelerating endocytosis and reducing surface expression. The Arc/Arg3.1-endocytosis pathway appears to regulate basal AMPAR levels since Arc/Arg3.1 KO neurons exhibit markedly reduced endocytosis and increased steady-state surface levels. These findings reveal a novel molecular pathway that is regulated by Arc/Arg3.1 and likely contributes to late-phase synaptic plasticity and memory consolidation."xsd:string |
| http://purl.uniprot.org/citations/17088211 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2006.08.033"xsd:string |
| http://purl.uniprot.org/citations/17088211 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2006.08.033"xsd:string |
| http://purl.uniprot.org/citations/17088211 | http://purl.uniprot.org/core/author | "Chowdhury S."xsd:string |
| http://purl.uniprot.org/citations/17088211 | http://purl.uniprot.org/core/author | "Chowdhury S."xsd:string |
| http://purl.uniprot.org/citations/17088211 | http://purl.uniprot.org/core/author | "Kuhl D."xsd:string |
| http://purl.uniprot.org/citations/17088211 | http://purl.uniprot.org/core/author | "Kuhl D."xsd:string |
| http://purl.uniprot.org/citations/17088211 | http://purl.uniprot.org/core/author | "Huganir R.L."xsd:string |
| http://purl.uniprot.org/citations/17088211 | http://purl.uniprot.org/core/author | "Huganir R.L."xsd:string |
| http://purl.uniprot.org/citations/17088211 | http://purl.uniprot.org/core/author | "Worley P.F."xsd:string |
| http://purl.uniprot.org/citations/17088211 | http://purl.uniprot.org/core/author | "Worley P.F."xsd:string |
| http://purl.uniprot.org/citations/17088211 | http://purl.uniprot.org/core/author | "Lyford G."xsd:string |
| http://purl.uniprot.org/citations/17088211 | http://purl.uniprot.org/core/author | "Lyford G."xsd:string |
| http://purl.uniprot.org/citations/17088211 | http://purl.uniprot.org/core/author | "Okuno H."xsd:string |
| http://purl.uniprot.org/citations/17088211 | http://purl.uniprot.org/core/author | "Okuno H."xsd:string |
| http://purl.uniprot.org/citations/17088211 | http://purl.uniprot.org/core/author | "Petralia R.S."xsd:string |
| http://purl.uniprot.org/citations/17088211 | http://purl.uniprot.org/core/author | "Petralia R.S."xsd:string |
| http://purl.uniprot.org/citations/17088211 | http://purl.uniprot.org/core/author | "Plath N."xsd:string |
| http://purl.uniprot.org/citations/17088211 | http://purl.uniprot.org/core/author | "Plath N."xsd:string |
| http://purl.uniprot.org/citations/17088211 | http://purl.uniprot.org/core/author | "Shepherd J.D."xsd:string |
| http://purl.uniprot.org/citations/17088211 | http://purl.uniprot.org/core/author | "Shepherd J.D."xsd:string |
| http://purl.uniprot.org/citations/17088211 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17088211 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |