| http://purl.uniprot.org/citations/17088212 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17088212 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17088212 | http://www.w3.org/2000/01/rdf-schema#comment | "Arc/Arg3.1 is an immediate-early gene whose expression levels are increased by strong synaptic activation, including synapse-strengthening activity patterns. Arc/Arg3.1 mRNA is transported to activated dendritic regions, conferring the distribution of Arc/Arg3.1 protein both temporal correlation with the inducing stimulus and spatial specificity. Here, we investigate the effect of increased Arc/Arg3.1 levels on synaptic transmission. Surprisingly, Arc/Arg3.1 reduces the amplitude of synaptic currents mediated by AMPA-type glutamate receptors (AMPARs). This effect is prevented by RNAi knockdown of Arc/Arg3.1, by deleting a region of Arc/Arg3.1 known to interact with endophilin 3 or by blocking clathrin-coated endocytosis of AMPARs. In the hippocampal slice, Arc/Arg3.1 results in removal of AMPARs composed of GluR2 and GluR3 subunits (GluR2/3). Finally, Arc/Arg3.1 expression occludes NMDAR-dependent long-term depression. Our results demonstrate that Arc/Arg3.1 reduces the number of GluR2/3 receptors leading to a decrease in AMPAR-mediated synaptic currents, consistent with a role in the homeostatic regulation of synaptic strength."xsd:string |
| http://purl.uniprot.org/citations/17088212 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2006.09.031"xsd:string |
| http://purl.uniprot.org/citations/17088212 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2006.09.031"xsd:string |
| http://purl.uniprot.org/citations/17088212 | http://purl.uniprot.org/core/author | "Worley P.F."xsd:string |
| http://purl.uniprot.org/citations/17088212 | http://purl.uniprot.org/core/author | "Worley P.F."xsd:string |
| http://purl.uniprot.org/citations/17088212 | http://purl.uniprot.org/core/author | "Cline H.T."xsd:string |
| http://purl.uniprot.org/citations/17088212 | http://purl.uniprot.org/core/author | "Cline H.T."xsd:string |
| http://purl.uniprot.org/citations/17088212 | http://purl.uniprot.org/core/author | "Lee-Osbourne J."xsd:string |
| http://purl.uniprot.org/citations/17088212 | http://purl.uniprot.org/core/author | "Lee-Osbourne J."xsd:string |
| http://purl.uniprot.org/citations/17088212 | http://purl.uniprot.org/core/author | "Malinow R."xsd:string |
| http://purl.uniprot.org/citations/17088212 | http://purl.uniprot.org/core/author | "Malinow R."xsd:string |
| http://purl.uniprot.org/citations/17088212 | http://purl.uniprot.org/core/author | "Rial Verde E.M."xsd:string |
| http://purl.uniprot.org/citations/17088212 | http://purl.uniprot.org/core/author | "Rial Verde E.M."xsd:string |
| http://purl.uniprot.org/citations/17088212 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17088212 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17088212 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/17088212 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/17088212 | http://purl.uniprot.org/core/pages | "461-474"xsd:string |
| http://purl.uniprot.org/citations/17088212 | http://purl.uniprot.org/core/pages | "461-474"xsd:string |
| http://purl.uniprot.org/citations/17088212 | http://purl.uniprot.org/core/title | "Increased expression of the immediate-early gene arc/arg3.1 reduces AMPA receptor-mediated synaptic transmission."xsd:string |
| http://purl.uniprot.org/citations/17088212 | http://purl.uniprot.org/core/title | "Increased expression of the immediate-early gene arc/arg3.1 reduces AMPA receptor-mediated synaptic transmission."xsd:string |
| http://purl.uniprot.org/citations/17088212 | http://purl.uniprot.org/core/volume | "52"xsd:string |
| http://purl.uniprot.org/citations/17088212 | http://purl.uniprot.org/core/volume | "52"xsd:string |