| http://purl.uniprot.org/citations/17088532 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17088532 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17088532 | http://www.w3.org/2000/01/rdf-schema#comment | "Wilms' tumor 1-associating protein (WTAP) has been reported to be a ubiquitously expressed nuclear protein. Although a relation to splicing factors has been postulated, its actual physiological function still remains to be elucidated. To investigate the role of WTAP, we generated WTAP-knockout mice and performed small interfering RNA (siRNA)-mediated knockdown analyses in primary cultured cells. In DNA microarrays using human umbilical vein endothelial cells, WTAP-targeted siRNA treatment resulted in markedly reduced expression of cell-cycle-related genes. siRNA-mediated WTAP knockdown down-regulated the stability of cyclin A2 mRNA through a nine-nucleotide essential sequence in cyclin A2 mRNA 3' UTR. WTAP knockdown induced G2 accumulation, which is partially rescued by adenoviral overexpression of cyclin A2. Moreover, WTAP-null mice exhibited proliferative failure with death resulting at approximately embryonic day 6.5, an etiology almost identical to cyclin A2-null mice. Collectively, these findings establish WTAP as an essential factor for the stabilization of cyclin A2 mRNA, thereby regulating G2/M cell-cycle transition."xsd:string |
| http://purl.uniprot.org/citations/17088532 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0608357103"xsd:string |
| http://purl.uniprot.org/citations/17088532 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0608357103"xsd:string |
| http://purl.uniprot.org/citations/17088532 | http://purl.uniprot.org/core/author | "Kodama T."xsd:string |
| http://purl.uniprot.org/citations/17088532 | http://purl.uniprot.org/core/author | "Kodama T."xsd:string |
| http://purl.uniprot.org/citations/17088532 | http://purl.uniprot.org/core/author | "Yamamoto M."xsd:string |
| http://purl.uniprot.org/citations/17088532 | http://purl.uniprot.org/core/author | "Yamamoto M."xsd:string |
| http://purl.uniprot.org/citations/17088532 | http://purl.uniprot.org/core/author | "Takada S."xsd:string |
| http://purl.uniprot.org/citations/17088532 | http://purl.uniprot.org/core/author | "Takada S."xsd:string |
| http://purl.uniprot.org/citations/17088532 | http://purl.uniprot.org/core/author | "Okayama H."xsd:string |
| http://purl.uniprot.org/citations/17088532 | http://purl.uniprot.org/core/author | "Okayama H."xsd:string |
| http://purl.uniprot.org/citations/17088532 | http://purl.uniprot.org/core/author | "Aburatani H."xsd:string |
| http://purl.uniprot.org/citations/17088532 | http://purl.uniprot.org/core/author | "Aburatani H."xsd:string |
| http://purl.uniprot.org/citations/17088532 | http://purl.uniprot.org/core/author | "Horiuchi K."xsd:string |
| http://purl.uniprot.org/citations/17088532 | http://purl.uniprot.org/core/author | "Horiuchi K."xsd:string |
| http://purl.uniprot.org/citations/17088532 | http://purl.uniprot.org/core/author | "Housman D.E."xsd:string |
| http://purl.uniprot.org/citations/17088532 | http://purl.uniprot.org/core/author | "Housman D.E."xsd:string |
| http://purl.uniprot.org/citations/17088532 | http://purl.uniprot.org/core/author | "Hamakubo T."xsd:string |
| http://purl.uniprot.org/citations/17088532 | http://purl.uniprot.org/core/author | "Hamakubo T."xsd:string |
| http://purl.uniprot.org/citations/17088532 | http://purl.uniprot.org/core/author | "Minami T."xsd:string |
| http://purl.uniprot.org/citations/17088532 | http://purl.uniprot.org/core/author | "Minami T."xsd:string |
| http://purl.uniprot.org/citations/17088532 | http://purl.uniprot.org/core/author | "Reid P.C."xsd:string |
| http://purl.uniprot.org/citations/17088532 | http://purl.uniprot.org/core/author | "Reid P.C."xsd:string |