| http://purl.uniprot.org/citations/17090532 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17090532 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17090532 | http://www.w3.org/2000/01/rdf-schema#comment | "Adiponectin is an adipose-derived hormone that plays an important role in maintaining energy homeostasis. Adiponectin gene expression is diminished in both obesity and type 2 diabetes. However, the mechanism underlying the impaired adiponectin gene expression remains poorly understood. Recent studies have indicated that forkhead transcription factor O1 (Foxo1) and silent information regulator 2 mammalian ortholog SIRT1 are involved in adipogenesis. Here we have shown that Foxo1 up-regulates adiponectin gene transcription through a Foxo1-responsive region in the mouse adiponectin promoter that contains two adjacent Foxo1 binding sites. Foxo1 interacts with CCAAT/enhancer-binding protein alpha (C/EBPalpha) to form a transcription complex at the mouse adiponectin promoter and up-regulates adiponectin gene transcription. Our study has revealed that C/EBPalpha accesses the adiponectin promoter through two Foxo1 binding sites and acts as a co-activator. Further, SIRT1 increases adiponectin transcription in adipocytes by activating Foxo1 and enhancing Foxo1 and C/EBPalpha interaction. Importantly, both Foxo1 and SIRT1 protein levels were significantly lower in epididymal fat tissues from db/db and high fat diet-induced obese mice compared with normal mice. We propose that low expression of SIRT1 and Foxo1 leads to impaired Foxo1-C/EBPalpha complex formation, which contributes to the diminished adiponectin expression in obesity and type 2 diabetes."xsd:string |
| http://purl.uniprot.org/citations/17090532 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m607215200"xsd:string |
| http://purl.uniprot.org/citations/17090532 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m607215200"xsd:string |
| http://purl.uniprot.org/citations/17090532 | http://purl.uniprot.org/core/author | "Shao J."xsd:string |
| http://purl.uniprot.org/citations/17090532 | http://purl.uniprot.org/core/author | "Shao J."xsd:string |
| http://purl.uniprot.org/citations/17090532 | http://purl.uniprot.org/core/author | "Qiao L."xsd:string |
| http://purl.uniprot.org/citations/17090532 | http://purl.uniprot.org/core/author | "Qiao L."xsd:string |
| http://purl.uniprot.org/citations/17090532 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17090532 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17090532 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/17090532 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/17090532 | http://purl.uniprot.org/core/pages | "39915-39924"xsd:string |
| http://purl.uniprot.org/citations/17090532 | http://purl.uniprot.org/core/pages | "39915-39924"xsd:string |
| http://purl.uniprot.org/citations/17090532 | http://purl.uniprot.org/core/title | "SIRT1 regulates adiponectin gene expression through Foxo1-C/enhancer-binding protein alpha transcriptional complex."xsd:string |
| http://purl.uniprot.org/citations/17090532 | http://purl.uniprot.org/core/title | "SIRT1 regulates adiponectin gene expression through Foxo1-C/enhancer-binding protein alpha transcriptional complex."xsd:string |
| http://purl.uniprot.org/citations/17090532 | http://purl.uniprot.org/core/volume | "281"xsd:string |
| http://purl.uniprot.org/citations/17090532 | http://purl.uniprot.org/core/volume | "281"xsd:string |
| http://purl.uniprot.org/citations/17090532 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17090532 |
| http://purl.uniprot.org/citations/17090532 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17090532 |
| http://purl.uniprot.org/citations/17090532 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17090532 |
| http://purl.uniprot.org/citations/17090532 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17090532 |
| http://purl.uniprot.org/uniprot/Q9R1E0 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/17090532 |
| http://purl.uniprot.org/uniprot/P53566 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/17090532 |