| http://purl.uniprot.org/citations/17090643 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17090643 | http://www.w3.org/2000/01/rdf-schema#comment | "ContextChildren with obesity [body mass index (BMI) > +2 sd score (SDS)] and children with constitutional tall stature [CTS; height > +2 SDS)] have normal-high serum IGF-I levels, associated with a low and broad range of GH secretion, respectively. This suggests increased sensitivity to GH, whereas children with idiopathic short stature (ISS; height < -2 SDS) are believed to have decreased GH sensitivity. OBJECTIVE, DESIGN, AND MAIN OUTCOME MEASURE: To compare the responsiveness to GH in 62 prepubertal children (43 females, 19 males) with obesity, CTS, or ISS and 26 controls (15 females, 11 males; height and BMI -2 to +2 SDS), we used an IGF-I generation test and studied the IGF-I concentration 24 h after a single injection of GH (2 mg/m2).PatientsTwenty patients with obesity, 20 with CTS, 22 with ISS, and 26 controls were studied. The mean age was 8.3 +/-2.9 yr, with no difference in age or gender between groups.ResultsCompared with controls, the mean IGF-I increment was 80% higher in obese children and 36% higher in tall children (P < 0.05 obese or tall vs. control children; P = 0.05 obese vs. tall children). Conversely, the IGF-I increment was similar in short compared with control children, despite a mean baseline IGF-I 62% lower in short children (P < 0.05 vs. controls). In all groups, the IGF-I increment was correlated with the BMI SDS or the fat mass percentage (r = 0.51-0.58, P < 0.05).ConclusionObese children tend to have greater GH responsiveness than tall children, and both have greater GH responsiveness than controls. GH responsiveness was similar in controls and short children, despite a lower baseline IGF-I in short children. Whether the differences in the IGF-I response to GH between these children reflect differences in the respective anabolic (growth promotion) and metabolic (i.e. insulin action modulation) roles of circulating IGF-I is unknown."xsd:string |
| http://purl.uniprot.org/citations/17090643 | http://purl.org/dc/terms/identifier | "doi:10.1210/jc.2005-2631"xsd:string |
| http://purl.uniprot.org/citations/17090643 | http://purl.uniprot.org/core/author | "Coutant R."xsd:string |
| http://purl.uniprot.org/citations/17090643 | http://purl.uniprot.org/core/author | "Bouhours-Nouet N."xsd:string |
| http://purl.uniprot.org/citations/17090643 | http://purl.uniprot.org/core/author | "Gatelais F."xsd:string |
| http://purl.uniprot.org/citations/17090643 | http://purl.uniprot.org/core/author | "Rouleau S."xsd:string |
| http://purl.uniprot.org/citations/17090643 | http://purl.uniprot.org/core/author | "Boux de Casson F."xsd:string |
| http://purl.uniprot.org/citations/17090643 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17090643 | http://purl.uniprot.org/core/name | "J Clin Endocrinol Metab"xsd:string |
| http://purl.uniprot.org/citations/17090643 | http://purl.uniprot.org/core/pages | "629-635"xsd:string |
| http://purl.uniprot.org/citations/17090643 | http://purl.uniprot.org/core/title | "The insulin-like growth factor-I response to growth hormone is increased in prepubertal children with obesity and tall stature."xsd:string |
| http://purl.uniprot.org/citations/17090643 | http://purl.uniprot.org/core/volume | "92"xsd:string |
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