| http://purl.uniprot.org/citations/17090653 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17090653 | http://www.w3.org/2000/01/rdf-schema#comment | "Neurofibromatosis type 1 (NF1) syndrome is caused by germline mutations in the NF1 tumor suppressor, which encodes neurofibromin, a GTPase activating protein for Ras. Children with NF1 are predisposed to juvenile myelomonocytic leukemia (JMML) and lethally irradiated mice given transplants with homozygous Nf1 mutant (Nf1-/-) hematopoietic stem cells develop a fatal myeloproliferative disorder (MPD) that models JMML. We investigated the requirement for signaling through the GM-CSF receptor to initiate and sustain this MPD by generating Nf1 mutant hematopoietic cells lacking the common beta chain (Beta c) of the GM-CSF receptor. Mice reconstituted with Nf1-/-, beta c-/-stem cells did not develop evidence of MPD despite the presence of increased number of immature hematopoietic progenitors in the bone marrow. Interestingly, when the Mx1-Cre transgene was used to inactivate a conditional Nf1 mutant allele in hematopoietic cells, concomitant loss of beta c-/-reduced the severity of the MPD, but did not abrogate it. Whereas inhibiting GM-CSF signaling may be of therapeutic benefit in JMML, our data also demonstrate aberrant proliferation of Nf1-/-myeloid progenitors that is independent of signaling through the GM-CSF receptor."xsd:string |
| http://purl.uniprot.org/citations/17090653 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2006-05-025395"xsd:string |
| http://purl.uniprot.org/citations/17090653 | http://purl.uniprot.org/core/author | "Kim A."xsd:string |
| http://purl.uniprot.org/citations/17090653 | http://purl.uniprot.org/core/author | "Largaespada D.A."xsd:string |
| http://purl.uniprot.org/citations/17090653 | http://purl.uniprot.org/core/author | "Morgan K."xsd:string |
| http://purl.uniprot.org/citations/17090653 | http://purl.uniprot.org/core/author | "Wiesner S.M."xsd:string |
| http://purl.uniprot.org/citations/17090653 | http://purl.uniprot.org/core/author | "Le D.T."xsd:string |
| http://purl.uniprot.org/citations/17090653 | http://purl.uniprot.org/core/author | "Kogan S.C."xsd:string |
| http://purl.uniprot.org/citations/17090653 | http://purl.uniprot.org/core/author | "Shannon K."xsd:string |
| http://purl.uniprot.org/citations/17090653 | http://purl.uniprot.org/core/author | "Lauchle J.O."xsd:string |
| http://purl.uniprot.org/citations/17090653 | http://purl.uniprot.org/core/author | "Hasz D.E."xsd:string |
| http://purl.uniprot.org/citations/17090653 | http://purl.uniprot.org/core/author | "Parada L.F."xsd:string |
| http://purl.uniprot.org/citations/17090653 | http://purl.uniprot.org/core/author | "Geurts J.L."xsd:string |
| http://purl.uniprot.org/citations/17090653 | http://purl.uniprot.org/core/author | "Diers M.D."xsd:string |
| http://purl.uniprot.org/citations/17090653 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17090653 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/17090653 | http://purl.uniprot.org/core/pages | "1687-1691"xsd:string |
| http://purl.uniprot.org/citations/17090653 | http://purl.uniprot.org/core/title | "Beta common receptor inactivation attenuates myeloproliferative disease in Nf1 mutant mice."xsd:string |
| http://purl.uniprot.org/citations/17090653 | http://purl.uniprot.org/core/volume | "109"xsd:string |
| http://purl.uniprot.org/citations/17090653 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17090653 |
| http://purl.uniprot.org/citations/17090653 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17090653 |
| http://purl.uniprot.org/uniprot/#_A0A2R8VHF2-mappedCitation-17090653 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17090653 |
| http://purl.uniprot.org/uniprot/#_A0A1W2P863-mappedCitation-17090653 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17090653 |
| http://purl.uniprot.org/uniprot/#_A0A2R8VK01-mappedCitation-17090653 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17090653 |