| http://purl.uniprot.org/citations/17090657 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17090657 | http://www.w3.org/2000/01/rdf-schema#comment | "CD34 cells from patients with trisomy 8 myelodysplastic syndrome (MDS) are distinguished from other MDS cells and from normal hematopoietic cells by their pronounced expression of apoptotic markers. Paradoxically, trisomy 8 clones can persist in patients with bone marrow failure and expand following immunosuppression. We previously demonstrated up-regulation of c-myc and CD1 by microarray analysis. Here, we confirmed these findings by real-time polymerase chain reaction (PCR), demonstrated up-regulation of survivin, c-myc, and CD1 protein expression, and documented comparable colony formation by annexin(+) trisomy 8(-) CD34(+) and annexin(-) CD34 cells. There were low levels of DNA degradation in annexin(+) trisomy 8 CD34 cells, which were comparable with annexin(-) CD34 cells. Trisomy 8 cells were resistant to apoptosis induced by gamma irradiation. Knock-down of survivin by siRNA resulted in preferential loss of trisomy 8 cells. These results suggest that trisomy 8 cells undergo incomplete apoptosis and are nonetheless capable of colony formation and growth."xsd:string |
| http://purl.uniprot.org/citations/17090657 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2006-01-030643"xsd:string |
| http://purl.uniprot.org/citations/17090657 | http://purl.uniprot.org/core/author | "Chen G."xsd:string |
| http://purl.uniprot.org/citations/17090657 | http://purl.uniprot.org/core/author | "Shah S."xsd:string |
| http://purl.uniprot.org/citations/17090657 | http://purl.uniprot.org/core/author | "Young N.S."xsd:string |
| http://purl.uniprot.org/citations/17090657 | http://purl.uniprot.org/core/author | "Barrett J."xsd:string |
| http://purl.uniprot.org/citations/17090657 | http://purl.uniprot.org/core/author | "Solomou E.E."xsd:string |
| http://purl.uniprot.org/citations/17090657 | http://purl.uniprot.org/core/author | "Pfannes L."xsd:string |
| http://purl.uniprot.org/citations/17090657 | http://purl.uniprot.org/core/author | "Sloand E.M."xsd:string |
| http://purl.uniprot.org/citations/17090657 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17090657 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/17090657 | http://purl.uniprot.org/core/pages | "2399-2405"xsd:string |
| http://purl.uniprot.org/citations/17090657 | http://purl.uniprot.org/core/title | "CD34 cells from patients with trisomy 8 myelodysplastic syndrome (MDS) express early apoptotic markers but avoid programmed cell death by up-regulation of antiapoptotic proteins."xsd:string |
| http://purl.uniprot.org/citations/17090657 | http://purl.uniprot.org/core/volume | "109"xsd:string |
| http://purl.uniprot.org/citations/17090657 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17090657 |
| http://purl.uniprot.org/citations/17090657 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17090657 |
| http://purl.uniprot.org/uniprot/#_B4DG27-mappedCitation-17090657 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17090657 |
| http://purl.uniprot.org/uniprot/#_A8KAG5-mappedCitation-17090657 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17090657 |
| http://purl.uniprot.org/uniprot/#_B4DUX4-mappedCitation-17090657 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17090657 |
| http://purl.uniprot.org/uniprot/#_P28906-mappedCitation-17090657 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17090657 |
| http://purl.uniprot.org/uniprot/#_Q3C1E7-mappedCitation-17090657 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17090657 |
| http://purl.uniprot.org/uniprot/#_Q8IUM0-mappedCitation-17090657 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17090657 |
| http://purl.uniprot.org/uniprot/#_Q7Z375-mappedCitation-17090657 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17090657 |
| http://purl.uniprot.org/uniprot/#_Q9UH97-mappedCitation-17090657 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17090657 |