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http://purl.uniprot.org/citations/17091455 | http://www.w3.org/2000/01/rdf-schema#comment | "IntroductionGalectin-3 (Gal-3), coding by LGALS3BP gene, is a protein of the lectin family that has been associated with neoplastic processes and seems to play an important role in a variety of cell biological processes. In the thyroid gland, the high expression of this protein has been described in differentiated carcinomas, especially in papillary thyroid cancer (PTC).AimAnalysis of Gal-3 protein expression in PTC and nodular goiters; investigation of Gal-3 mRNA expression in peripheral blood lymphocytes (PBL) in patients with PTC and nodular goiter; analysis of correlation between Gal-3 protein expression in PTC and Gal-3 mRNA in PBL of the same patient.Material and methodsGal-3 protein was evaluated by immunohistochemistry in benign (27 multinodular goiters) and malignant (30 papillary carcinomas) thyroid tissues and galectin-3 mRNA expression by real-time PCR in peripheral blood lymphocytes (PBL) from 90 patients with multinodular goiter (n = 27), papillary carcinoma (n = 30) and healthy controls (n = 33).ResultsIn PTC we observed increased expression of Gal-3 protein (all 30 cases) in cytoplasm, nucleus and cell membranes of cancer cells. 23 of 27 benign thyroid nodular goiters were negative for Gal-3 expression. In all examined blood samples we observed higher LGALS3BP gene expression than GAPDH (house keeping gene) with no difference between both groups, without relation to the Gal-3 expression in PTC.ConclusionsThere is no difference in Gal-3 expression in peripheral blood lymphocytes in patients with papillary thyroid cancer in relation to nodular goiter."xsd:string |
http://purl.uniprot.org/citations/17091455 | http://purl.uniprot.org/core/author | "Dobosz T."xsd:string |
http://purl.uniprot.org/citations/17091455 | http://purl.uniprot.org/core/author | "Rzeszutko M."xsd:string |
http://purl.uniprot.org/citations/17091455 | http://purl.uniprot.org/core/author | "Kaliszewski K."xsd:string |
http://purl.uniprot.org/citations/17091455 | http://purl.uniprot.org/core/author | "Lukienczuk T."xsd:string |
http://purl.uniprot.org/citations/17091455 | http://purl.uniprot.org/core/author | "Sadakierska-Chudy A."xsd:string |
http://purl.uniprot.org/citations/17091455 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
http://purl.uniprot.org/citations/17091455 | http://purl.uniprot.org/core/name | "Endokrynol Pol 57 Suppl"xsd:string |
http://purl.uniprot.org/citations/17091455 | http://purl.uniprot.org/core/pages | "38-44"xsd:string |
http://purl.uniprot.org/citations/17091455 | http://purl.uniprot.org/core/title | "[Analysis of expression of LGALS3BP gene in thyroid tissues and peripheral blood lymphocytes in patients with papillary thyroid cancer]."xsd:string |
http://purl.uniprot.org/citations/17091455 | http://purl.uniprot.org/core/volume | "A"xsd:string |
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