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| http://purl.uniprot.org/citations/17092488 | http://www.w3.org/2000/01/rdf-schema#comment | "Scavenger receptors internalize chemically modified low density lipoprotein particles (ac-LDL) and other ligands through the process of receptor-mediated endocytosis. During this investigation using amyloid-beta as a natural ligand for the SR, we studied under a ligand-induced oxidative stress condition, changes in protein expression of several adaptor proteins important in the organization of the endocytic machinery in microglia and macrophages. Differential expression experiments of beta-adaptin, alpha-adaptin, SR-AI, and SR-BI in RAW (macrophages) and EOC (microglia) cells were performed according to dosage and exposure time to amyloid-beta. Our results show that according to dosage, amyloid-beta produces an oxidative stress state that importantly affects the availability of beta-adaptin. Under these conditions, RT-PCR assays show that beta-adaptin mRNA is normally synthesized, reason why protein translation or protein structure of beta-adaptin might be altered. These observations might have impact in the understanding of the mechanisms microglia employ to process amyloid-beta in the brain."xsd:string |
| http://purl.uniprot.org/citations/17092488 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2006.10.077"xsd:string |
| http://purl.uniprot.org/citations/17092488 | http://purl.uniprot.org/core/author | "Mas-Oliva J."xsd:string |
| http://purl.uniprot.org/citations/17092488 | http://purl.uniprot.org/core/author | "Delgado-Coello B."xsd:string |
| http://purl.uniprot.org/citations/17092488 | http://purl.uniprot.org/core/author | "Guaderrama-Diaz M."xsd:string |
| http://purl.uniprot.org/citations/17092488 | http://purl.uniprot.org/core/author | "Manzano-Leon N."xsd:string |
| http://purl.uniprot.org/citations/17092488 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17092488 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/17092488 | http://purl.uniprot.org/core/pages | "588-594"xsd:string |
| http://purl.uniprot.org/citations/17092488 | http://purl.uniprot.org/core/title | "Beta-adaptin: key molecule for microglial scavenger receptor function under oxidative stress."xsd:string |
| http://purl.uniprot.org/citations/17092488 | http://purl.uniprot.org/core/volume | "351"xsd:string |
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