| http://purl.uniprot.org/citations/17097562 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17097562 | http://www.w3.org/2000/01/rdf-schema#comment | "Tribbles homolog 2 (Trib2) was identified as a downregulated transcript in leukemic cells undergoing growth arrest. To investigate the effects of Trib2 in hematopoietic progenitors, mice were reconstituted with hematopoietic stem cells retrovirally expressing Trib2. Trib2-transduced bone marrow cells exhibited a growth advantage ex vivo and readily established factor-dependent cell lines. In vivo, Trib2-reconstituted mice uniformly developed fatal transplantable acute myelogenous leukemia (AML). In mechanistic studies, we found that Trib2 associated with and inhibited C/EBPalpha. Furthermore, Trib2 expression was elevated in a subset of human AML patient samples. Together, our data identify Trib2 as an oncogene that induces AML through a mechanism involving inactivation of C/EBPalpha."xsd:string |
| http://purl.uniprot.org/citations/17097562 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ccr.2006.09.012"xsd:string |
| http://purl.uniprot.org/citations/17097562 | http://purl.uniprot.org/core/author | "He Y."xsd:string |
| http://purl.uniprot.org/citations/17097562 | http://purl.uniprot.org/core/author | "Xu L."xsd:string |
| http://purl.uniprot.org/citations/17097562 | http://purl.uniprot.org/core/author | "Maillard I."xsd:string |
| http://purl.uniprot.org/citations/17097562 | http://purl.uniprot.org/core/author | "Pear W.S."xsd:string |
| http://purl.uniprot.org/citations/17097562 | http://purl.uniprot.org/core/author | "Tobias J.W."xsd:string |
| http://purl.uniprot.org/citations/17097562 | http://purl.uniprot.org/core/author | "Carroll M."xsd:string |
| http://purl.uniprot.org/citations/17097562 | http://purl.uniprot.org/core/author | "Aster J.C."xsd:string |
| http://purl.uniprot.org/citations/17097562 | http://purl.uniprot.org/core/author | "Delwel R."xsd:string |
| http://purl.uniprot.org/citations/17097562 | http://purl.uniprot.org/core/author | "Keeshan K."xsd:string |
| http://purl.uniprot.org/citations/17097562 | http://purl.uniprot.org/core/author | "Shestova O."xsd:string |
| http://purl.uniprot.org/citations/17097562 | http://purl.uniprot.org/core/author | "Rodriguez C.G."xsd:string |
| http://purl.uniprot.org/citations/17097562 | http://purl.uniprot.org/core/author | "Sai H."xsd:string |
| http://purl.uniprot.org/citations/17097562 | http://purl.uniprot.org/core/author | "Valk P."xsd:string |
| http://purl.uniprot.org/citations/17097562 | http://purl.uniprot.org/core/author | "Wouters B.J."xsd:string |
| http://purl.uniprot.org/citations/17097562 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17097562 | http://purl.uniprot.org/core/name | "Cancer Cell"xsd:string |
| http://purl.uniprot.org/citations/17097562 | http://purl.uniprot.org/core/pages | "401-411"xsd:string |
| http://purl.uniprot.org/citations/17097562 | http://purl.uniprot.org/core/title | "Tribbles homolog 2 inactivates C/EBPalpha and causes acute myelogenous leukemia."xsd:string |
| http://purl.uniprot.org/citations/17097562 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/17097562 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17097562 |
| http://purl.uniprot.org/citations/17097562 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17097562 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RPE0-mappedCitation-17097562 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17097562 |