| http://purl.uniprot.org/citations/17097563 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17097563 | http://www.w3.org/2000/01/rdf-schema#comment | "In neuroblastoma specimens, HIF-2alpha but not HIF-1alpha is strongly expressed in well-vascularized areas. In vitro, HIF-2alpha protein was stabilized at 5% O2 (resembling end capillary oxygen conditions) and, in contrast to the low HIF-1alpha activity at this oxygen level, actively transcribed genes like VEGF. Under hypoxia (1% O2), HIF-1alpha was transiently stabilized and primarily mediated acute responses, whereas HIF-2alpha protein gradually accumulated and governed prolonged hypoxic gene activation. Knockdown of HIF-2alpha reduced growth of neuroblastoma tumors in athymic mice. Furthermore, high HIF-2alpha protein levels were correlated with advanced clinical stage and high VEGF expression and predicted poor prognosis in a clinical neuroblastoma material. Our results demonstrate the relevance of HIF-2alpha in neuroblastoma progression and have general tumor biological implications."xsd:string |
| http://purl.uniprot.org/citations/17097563 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ccr.2006.08.026"xsd:string |
| http://purl.uniprot.org/citations/17097563 | http://purl.uniprot.org/core/author | "Borg A."xsd:string |
| http://purl.uniprot.org/citations/17097563 | http://purl.uniprot.org/core/author | "Nilsson H."xsd:string |
| http://purl.uniprot.org/citations/17097563 | http://purl.uniprot.org/core/author | "Navarro S."xsd:string |
| http://purl.uniprot.org/citations/17097563 | http://purl.uniprot.org/core/author | "Gradin K."xsd:string |
| http://purl.uniprot.org/citations/17097563 | http://purl.uniprot.org/core/author | "Poellinger L."xsd:string |
| http://purl.uniprot.org/citations/17097563 | http://purl.uniprot.org/core/author | "Fredlund E."xsd:string |
| http://purl.uniprot.org/citations/17097563 | http://purl.uniprot.org/core/author | "Vallon-Christersson J."xsd:string |
| http://purl.uniprot.org/citations/17097563 | http://purl.uniprot.org/core/author | "Pahlman S."xsd:string |
| http://purl.uniprot.org/citations/17097563 | http://purl.uniprot.org/core/author | "Lofstedt T."xsd:string |
| http://purl.uniprot.org/citations/17097563 | http://purl.uniprot.org/core/author | "Holmquist-Mengelbier L."xsd:string |
| http://purl.uniprot.org/citations/17097563 | http://purl.uniprot.org/core/author | "Noguera R."xsd:string |
| http://purl.uniprot.org/citations/17097563 | http://purl.uniprot.org/core/author | "Pietras A."xsd:string |
| http://purl.uniprot.org/citations/17097563 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17097563 | http://purl.uniprot.org/core/name | "Cancer Cell"xsd:string |
| http://purl.uniprot.org/citations/17097563 | http://purl.uniprot.org/core/pages | "413-423"xsd:string |
| http://purl.uniprot.org/citations/17097563 | http://purl.uniprot.org/core/title | "Recruitment of HIF-1alpha and HIF-2alpha to common target genes is differentially regulated in neuroblastoma: HIF-2alpha promotes an aggressive phenotype."xsd:string |
| http://purl.uniprot.org/citations/17097563 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/17097563 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17097563 |
| http://purl.uniprot.org/citations/17097563 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17097563 |
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| http://purl.uniprot.org/uniprot/#_Q53ST6-mappedCitation-17097563 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17097563 |