| http://purl.uniprot.org/citations/17101770 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17101770 | http://www.w3.org/2000/01/rdf-schema#comment | "CD8+ T-cell apoptosis is essential for the contraction phase of the immune response, yet the initiating signals and precise pathways involved are unresolved. The ST3Gal-I sialyltransferase is a candidate mechanistic component and catalyzes sialic acid addition to core 1 O-glycans during protein O glycosylation. ST3Gal-I inactivation or enzymatic removal of its product renders CD8+ T cells, but not CD4+ T cells, susceptible to apoptosis by differential cross-linking of O-glycoproteins in the absence of interleukin-2 and T-cell receptor (TCR) signaling. This results in caspase activation, DNA fragmentation, and phosphatidylserine externalization prior to cell death. We further show that ST3Gal-I function is regulated by a posttranscriptional mechanism operating distal to Golgi core 2 O glycosylation and is invariably linked to CD8+ T-cell contraction following viral (lymphocytic choriomeningitis virus) infection and bacterial (staphylococcal enterotoxin B) antigen immunization. The mechanism does not involve the ST3Gal-I substrate CD43 or core 2 O-glycan induction and overcomes the ability of Bcl-2 to inhibit the contraction phase in vivo. Loss of ST3Gal-I function further reduces Bim-deficient CD8+ T-cell accumulation without diminishing apoptotic sensitivity. We propose that an endogenous lectin activates an apoptotic pathway constructed in CD8+ T cells following TCR stimulation and enables contraction upon attenuation of immune signaling."xsd:string |
| http://purl.uniprot.org/citations/17101770 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.01750-06"xsd:string |
| http://purl.uniprot.org/citations/17101770 | http://purl.uniprot.org/core/author | "Marth J.D."xsd:string |
| http://purl.uniprot.org/citations/17101770 | http://purl.uniprot.org/core/author | "Green R.S."xsd:string |
| http://purl.uniprot.org/citations/17101770 | http://purl.uniprot.org/core/author | "Van Dyken S.J."xsd:string |
| http://purl.uniprot.org/citations/17101770 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17101770 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/17101770 | http://purl.uniprot.org/core/pages | "1096-1111"xsd:string |
| http://purl.uniprot.org/citations/17101770 | http://purl.uniprot.org/core/title | "Structural and mechanistic features of protein O glycosylation linked to CD8+ T-cell apoptosis."xsd:string |
| http://purl.uniprot.org/citations/17101770 | http://purl.uniprot.org/core/volume | "27"xsd:string |
| http://purl.uniprot.org/citations/17101770 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17101770 |
| http://purl.uniprot.org/citations/17101770 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17101770 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RNN5-mappedCitation-17101770 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17101770 |
| http://purl.uniprot.org/uniprot/#_A0A1Z4EAV4-mappedCitation-17101770 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17101770 |
| http://purl.uniprot.org/uniprot/#_A0A1W2P6F0-mappedCitation-17101770 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17101770 |
| http://purl.uniprot.org/uniprot/#_P15702-mappedCitation-17101770 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17101770 |
| http://purl.uniprot.org/uniprot/#_Q11201-mappedCitation-17101770 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17101770 |
| http://purl.uniprot.org/uniprot/#_O54918-mappedCitation-17101770 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17101770 |
| http://purl.uniprot.org/uniprot/#_Q3UN35-mappedCitation-17101770 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17101770 |
| http://purl.uniprot.org/uniprot/#_Q6PEB3-mappedCitation-17101770 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17101770 |
| http://purl.uniprot.org/uniprot/#_Q09200-mappedCitation-17101770 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17101770 |
| http://purl.uniprot.org/uniprot/#_Q09324-mappedCitation-17101770 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17101770 |
| http://purl.uniprot.org/uniprot/#_P54751-mappedCitation-17101770 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17101770 |
| http://purl.uniprot.org/uniprot/#_Q3TR86-mappedCitation-17101770 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17101770 |