| http://purl.uniprot.org/citations/17101801 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17101801 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17101801 | http://www.w3.org/2000/01/rdf-schema#comment | "c-Jun, a major transcription factor in the activating protein 1 family of regulatory proteins, is activated by many physiologic and pathological stimuli. We show here that c-Jun was downregulated in response to osmotic stress via ubiquitination-dependent degradation by the PHD/RING finger domain of MEKK1, which exhibited E3 ubiquitin ligase activity toward c-Jun in vitro and in vivo. The reduced c-Jun protein level resulting from exogenous expression of wild-type MEKK1 and the opposite effect induced by expression of a MEKK1 PHD/RING finger domain mutant were consistent with a higher level of c-Jun protein in MEKK1(-/-) cells than in corresponding wild-type cells. The deficiency of MEKK1 blocked posttranslational downregulation of c-Jun in response to osmotic stress. Furthermore, apoptosis induced by osmotic stress was suppressed by overexpression of c-Jun, indicating that the downregulation of c-Jun promotes apoptosis."xsd:string |
| http://purl.uniprot.org/citations/17101801 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.01355-06"xsd:string |
| http://purl.uniprot.org/citations/17101801 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.01355-06"xsd:string |
| http://purl.uniprot.org/citations/17101801 | http://purl.uniprot.org/core/author | "Lu Z."xsd:string |
| http://purl.uniprot.org/citations/17101801 | http://purl.uniprot.org/core/author | "Lu Z."xsd:string |
| http://purl.uniprot.org/citations/17101801 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/17101801 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/17101801 | http://purl.uniprot.org/core/author | "Xia Y."xsd:string |
| http://purl.uniprot.org/citations/17101801 | http://purl.uniprot.org/core/author | "Xia Y."xsd:string |
| http://purl.uniprot.org/citations/17101801 | http://purl.uniprot.org/core/author | "Xu S."xsd:string |
| http://purl.uniprot.org/citations/17101801 | http://purl.uniprot.org/core/author | "Xu S."xsd:string |
| http://purl.uniprot.org/citations/17101801 | http://purl.uniprot.org/core/author | "Hunter T."xsd:string |
| http://purl.uniprot.org/citations/17101801 | http://purl.uniprot.org/core/author | "Hunter T."xsd:string |
| http://purl.uniprot.org/citations/17101801 | http://purl.uniprot.org/core/author | "Johnson G.L."xsd:string |
| http://purl.uniprot.org/citations/17101801 | http://purl.uniprot.org/core/author | "Johnson G.L."xsd:string |
| http://purl.uniprot.org/citations/17101801 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17101801 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17101801 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/17101801 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/17101801 | http://purl.uniprot.org/core/pages | "510-517"xsd:string |
| http://purl.uniprot.org/citations/17101801 | http://purl.uniprot.org/core/pages | "510-517"xsd:string |
| http://purl.uniprot.org/citations/17101801 | http://purl.uniprot.org/core/title | "MEKK1 mediates the ubiquitination and degradation of c-Jun in response to osmotic stress."xsd:string |
| http://purl.uniprot.org/citations/17101801 | http://purl.uniprot.org/core/title | "MEKK1 mediates the ubiquitination and degradation of c-Jun in response to osmotic stress."xsd:string |