| http://purl.uniprot.org/citations/17105346 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17105346 | http://www.w3.org/2000/01/rdf-schema#comment | "Proliferating cell nuclear antigen (PCNA) is a DNA polymerase cofactor and regulator of replication-linked functions. Upon DNA damage, yeast and vertebrate PCNA is modified at the conserved lysine K164 by ubiquitin, which mediates error-prone replication across lesions via translesion polymerases. We investigated the role of PCNA ubiquitination in variants of the DT40 B cell line that are mutant in K164 of PCNA or in Rad18, which is involved in PCNA ubiquitination. Remarkably, the PCNA(K164R) mutation not only renders cells sensitive to DNA-damaging agents, but also strongly reduces activation induced deaminase-dependent single-nucleotide substitutions in the immunoglobulin light-chain locus. This is the first evidence, to our knowledge, that vertebrates exploit the PCNA-ubiquitin pathway for immunoglobulin hypermutation, most likely through the recruitment of error-prone DNA polymerases."xsd:string |
| http://purl.uniprot.org/citations/17105346 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pbio.0040366"xsd:string |
| http://purl.uniprot.org/citations/17105346 | http://purl.uniprot.org/core/author | "Arakawa H."xsd:string |
| http://purl.uniprot.org/citations/17105346 | http://purl.uniprot.org/core/author | "Jentsch S."xsd:string |
| http://purl.uniprot.org/citations/17105346 | http://purl.uniprot.org/core/author | "Moldovan G.L."xsd:string |
| http://purl.uniprot.org/citations/17105346 | http://purl.uniprot.org/core/author | "Saribasak H."xsd:string |
| http://purl.uniprot.org/citations/17105346 | http://purl.uniprot.org/core/author | "Buerstedde J.M."xsd:string |
| http://purl.uniprot.org/citations/17105346 | http://purl.uniprot.org/core/author | "Saribasak N.N."xsd:string |
| http://purl.uniprot.org/citations/17105346 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17105346 | http://purl.uniprot.org/core/name | "PLoS Biol"xsd:string |
| http://purl.uniprot.org/citations/17105346 | http://purl.uniprot.org/core/pages | "e366"xsd:string |
| http://purl.uniprot.org/citations/17105346 | http://purl.uniprot.org/core/title | "A role for PCNA ubiquitination in immunoglobulin hypermutation."xsd:string |
| http://purl.uniprot.org/citations/17105346 | http://purl.uniprot.org/core/volume | "4"xsd:string |
| http://purl.uniprot.org/citations/17105346 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17105346 |
| http://purl.uniprot.org/citations/17105346 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17105346 |
| http://purl.uniprot.org/uniprot/#_P15873-mappedCitation-17105346 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17105346 |
| http://purl.uniprot.org/uniprot/P15873 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17105346 |