| http://purl.uniprot.org/citations/17111351 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17111351 | http://www.w3.org/2000/01/rdf-schema#comment | "L-selectin belongs to the C-type lectin family of glycoproteins and is constitutively expressed on most leukocytes. L-selectin mediates leukocyte rolling in inflamed microvessels and high endothelial venules (HEV) via binding to specific carbohydrate structures on selectin ligands. Previous studies using sialidase treatment suggested a role of sialic acid residues in L-selectin-dependent rolling. To investigate the role of the alpha2,3-sialyltransferase (ST3Gal)-IV on L-selectin ligand activity in vivo, we studied leukocyte rolling in inflamed venules of the cremaster muscle and in Peyer's patch HEV of ST3Gal-IV-deficient mice and littermate control mice. In cremaster muscle venules with or without TNF-alpha treatment, L-selectin-dependent rolling was almost completely abolished in ST3Gal-IV(-/-) mice. In both models, L-selectin interacts with P-selectin glycoprotein ligand-1 (PSGL-1) presented by adherent leukocytes and leukocyte fragments, but not with endothelial L-selectin ligands. In contrast, L-selectin-dependent rolling in Peyer's patch HEV, which is mediated by unknown endothelial L-selectin ligands, was not impaired in the absence of ST3Gal-IV. Our in vivo data show that PSGL-1, the molecule responsible for L-selectin-mediated leukocyte interactions in inflammation, is dependent on ST3Gal-IV, while alpha2,3-sialylation by ST3Gal-IV is not necessary for L-selectin ligand activity on high endothelial cells of Peyer's patch HEV."xsd:string |
| http://purl.uniprot.org/citations/17111351 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.200636157"xsd:string |
| http://purl.uniprot.org/citations/17111351 | http://purl.uniprot.org/core/author | "Smith M.L."xsd:string |
| http://purl.uniprot.org/citations/17111351 | http://purl.uniprot.org/core/author | "Smith D.F."xsd:string |
| http://purl.uniprot.org/citations/17111351 | http://purl.uniprot.org/core/author | "Ellies L.G."xsd:string |
| http://purl.uniprot.org/citations/17111351 | http://purl.uniprot.org/core/author | "Marth J.D."xsd:string |
| http://purl.uniprot.org/citations/17111351 | http://purl.uniprot.org/core/author | "Pauly E."xsd:string |
| http://purl.uniprot.org/citations/17111351 | http://purl.uniprot.org/core/author | "Ley K."xsd:string |
| http://purl.uniprot.org/citations/17111351 | http://purl.uniprot.org/core/author | "Olson T.S."xsd:string |
| http://purl.uniprot.org/citations/17111351 | http://purl.uniprot.org/core/author | "Sperandio M."xsd:string |
| http://purl.uniprot.org/citations/17111351 | http://purl.uniprot.org/core/author | "Babushkina I."xsd:string |
| http://purl.uniprot.org/citations/17111351 | http://purl.uniprot.org/core/author | "Frommhold D."xsd:string |
| http://purl.uniprot.org/citations/17111351 | http://purl.uniprot.org/core/author | "Fritzsching B."xsd:string |
| http://purl.uniprot.org/citations/17111351 | http://purl.uniprot.org/core/author | "Linderkamp O."xsd:string |
| http://purl.uniprot.org/citations/17111351 | http://purl.uniprot.org/core/author | "Nobiling R."xsd:string |
| http://purl.uniprot.org/citations/17111351 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17111351 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/17111351 | http://purl.uniprot.org/core/pages | "3207-3215"xsd:string |
| http://purl.uniprot.org/citations/17111351 | http://purl.uniprot.org/core/title | "Alpha 2,3-sialyltransferase-IV is essential for L-selectin ligand function in inflammation."xsd:string |
| http://purl.uniprot.org/citations/17111351 | http://purl.uniprot.org/core/volume | "36"xsd:string |
| http://purl.uniprot.org/citations/17111351 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17111351 |
| http://purl.uniprot.org/citations/17111351 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17111351 |
| http://purl.uniprot.org/uniprot/#_A0A1L1SSB1-mappedCitation-17111351 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17111351 |
| http://purl.uniprot.org/uniprot/#_A0A1L1ST66-mappedCitation-17111351 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17111351 |