| http://purl.uniprot.org/citations/17113033 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17113033 | http://www.w3.org/2000/01/rdf-schema#comment | "Discoidin domain receptors (DDRs), DDR1 and DDR2, are non-integrin receptor tyrosine kinases for collagen in many cell types. In this study, we investigated the contributions of DDRs to the activation of mouse bone marrow-derived dendritic cells (DCs) by type I collagen (ColI). Our data showed that transcript and protein of DDR2 were expressed constitutively in immature DCs and upregulated in TNF-alpha-stimulated mature DCs. ColI treatment induced DDR2 phosphorylation and subsequently induced the upregulation of IL-12 production, CD86 expression, and antigen uptake activity by immature DCs. Depletion of DDR2 by specific siRNA attenuated significantly an increase in expression of IL-12 and CD86 in ColI-treated DCs. Additionally, DDR2-ColI interaction upregulated the ability of mature DCs to activate allogeneic T cells. These findings suggest that DDR2 is a critical collagen receptor for DC activation and that DDR2-collagen interaction plays an important role in the functional capacity of DCs regulating immune responses."xsd:string |
| http://purl.uniprot.org/citations/17113033 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2006.11.010"xsd:string |
| http://purl.uniprot.org/citations/17113033 | http://purl.uniprot.org/core/author | "Kim S.H."xsd:string |
| http://purl.uniprot.org/citations/17113033 | http://purl.uniprot.org/core/author | "Kim D.K."xsd:string |
| http://purl.uniprot.org/citations/17113033 | http://purl.uniprot.org/core/author | "Lee Y.M."xsd:string |
| http://purl.uniprot.org/citations/17113033 | http://purl.uniprot.org/core/author | "Lee J.E."xsd:string |
| http://purl.uniprot.org/citations/17113033 | http://purl.uniprot.org/core/author | "Kang C.S."xsd:string |
| http://purl.uniprot.org/citations/17113033 | http://purl.uniprot.org/core/author | "Kim B.T."xsd:string |
| http://purl.uniprot.org/citations/17113033 | http://purl.uniprot.org/core/author | "Moon W.S."xsd:string |
| http://purl.uniprot.org/citations/17113033 | http://purl.uniprot.org/core/author | "Guan X.Y."xsd:string |
| http://purl.uniprot.org/citations/17113033 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17113033 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/17113033 | http://purl.uniprot.org/core/pages | "244-250"xsd:string |
| http://purl.uniprot.org/citations/17113033 | http://purl.uniprot.org/core/title | "Discoidin domain receptor 2 is involved in the activation of bone marrow-derived dendritic cells caused by type I collagen."xsd:string |
| http://purl.uniprot.org/citations/17113033 | http://purl.uniprot.org/core/volume | "352"xsd:string |
| http://purl.uniprot.org/citations/17113033 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17113033 |
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