| http://purl.uniprot.org/citations/17113876 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17113876 | http://www.w3.org/2000/01/rdf-schema#comment | "The biosynthesis of the core 1 O-glycan (Galbeta1-3GalNAcalpha1-Ser/Thr, T antigen) is controlled by core 1 beta1-3-galactosyltransferase (T-synthase), which catalyzes the addition of Gal to GalNAcalpha1-Ser/Thr (Tn antigen). The T antigen is a precursor for extended and branched O-glycans of largely unknown function. We found that wild-type mice expressed the sialyl-T antigen (NeuAcalpha2-3Galbeta1-3GalNAcalpha1-Ser/Thr) primarily in endothelial, hematopoietic, and epithelial cells during development. Gene-targeted mice lacking T-synthase instead expressed the nonsialylated Tn antigen in these cells and developed brain hemorrhage that was uniformly fatal by embryonic day 14. T-synthase-deficient brains formed a chaotic microvascular network with distorted capillary lumens and defective association of endothelial cells with pericytes and extracellular matrix. These data reveal an unexpected requirement for core 1-derived O-glycans during angiogenesis."xsd:string |
| http://purl.uniprot.org/citations/17113876 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0076-6879(06)16021-8"xsd:string |
| http://purl.uniprot.org/citations/17113876 | http://purl.uniprot.org/core/author | "Xia L."xsd:string |
| http://purl.uniprot.org/citations/17113876 | http://purl.uniprot.org/core/author | "McEver R.P."xsd:string |
| http://purl.uniprot.org/citations/17113876 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17113876 | http://purl.uniprot.org/core/name | "Methods Enzymol"xsd:string |
| http://purl.uniprot.org/citations/17113876 | http://purl.uniprot.org/core/pages | "314-331"xsd:string |
| http://purl.uniprot.org/citations/17113876 | http://purl.uniprot.org/core/title | "Targeted disruption of the gene encoding core 1 beta1-3-galactosyltransferase (T-synthase) causes embryonic lethality and defective angiogenesis in mice."xsd:string |
| http://purl.uniprot.org/citations/17113876 | http://purl.uniprot.org/core/volume | "416"xsd:string |
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