| http://purl.uniprot.org/citations/17114795 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17114795 | http://www.w3.org/2000/01/rdf-schema#comment | "In germ line cells, recombination is required for gene reassortment and proper chromosome segregation at meiosis, whereas in somatic cells it provides an important mechanism for the repair of DNA double-strand breaks. Five proteins (RAD51B, RAD51C, RAD51D, XRCC2, and XRCC3) that share homology with RAD51 recombinase and are known as the RAD51 paralogs are important for recombinational repair, as paralog-defective cell lines exhibit spontaneous chromosomal aberrations, defective DNA repair, and reduced gene targeting. The paralogs form two distinct protein complexes, RAD51B-RAD51C-RAD51D-XRCC2 and RAD51C-XRCC3, but their precise cellular roles remain unknown. Here, we show that, like MLH1, RAD51C localized to mouse meiotic chromosomes at pachytene/diplotene. Using immunoprecipitation and gel filtration analyses, we found that Holliday junction resolvase activity associated tightly and co-eluted with the 80-kDa RAD51C-XRCC3 complex. Taken together, these data indicate that the RAD51C-XRCC3-associated Holliday junction resolvase complex associates with crossovers and may play an essential role in the resolution of recombination intermediates prior to chromosome segregation."xsd:string |
| http://purl.uniprot.org/citations/17114795 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m609066200"xsd:string |
| http://purl.uniprot.org/citations/17114795 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/17114795 | http://purl.uniprot.org/core/author | "West S.C."xsd:string |
| http://purl.uniprot.org/citations/17114795 | http://purl.uniprot.org/core/author | "Tarsounas M."xsd:string |
| http://purl.uniprot.org/citations/17114795 | http://purl.uniprot.org/core/author | "O'regan P."xsd:string |
| http://purl.uniprot.org/citations/17114795 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17114795 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/17114795 | http://purl.uniprot.org/core/pages | "1973-1979"xsd:string |
| http://purl.uniprot.org/citations/17114795 | http://purl.uniprot.org/core/title | "Role of RAD51C and XRCC3 in genetic recombination and DNA repair."xsd:string |
| http://purl.uniprot.org/citations/17114795 | http://purl.uniprot.org/core/volume | "282"xsd:string |
| http://purl.uniprot.org/citations/17114795 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17114795 |
| http://purl.uniprot.org/citations/17114795 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17114795 |
| http://purl.uniprot.org/uniprot/#_P54132-mappedCitation-17114795 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17114795 |
| http://purl.uniprot.org/uniprot/#_Q14191-mappedCitation-17114795 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17114795 |
| http://purl.uniprot.org/uniprot/#_A0A8V8TMU8-mappedCitation-17114795 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17114795 |
| http://purl.uniprot.org/uniprot/#_B4E0G0-mappedCitation-17114795 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17114795 |
| http://purl.uniprot.org/uniprot/#_O15315-mappedCitation-17114795 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17114795 |
| http://purl.uniprot.org/uniprot/#_P49959-mappedCitation-17114795 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17114795 |
| http://purl.uniprot.org/uniprot/#_Q53XC8-mappedCitation-17114795 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17114795 |
| http://purl.uniprot.org/uniprot/#_Q13472-mappedCitation-17114795 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17114795 |
| http://purl.uniprot.org/uniprot/#_P38398-mappedCitation-17114795 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17114795 |
| http://purl.uniprot.org/uniprot/#_Q06609-mappedCitation-17114795 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17114795 |
| http://purl.uniprot.org/uniprot/#_O75771-mappedCitation-17114795 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17114795 |