| http://purl.uniprot.org/citations/17115716 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17115716 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17115716 | http://www.w3.org/2000/01/rdf-schema#comment | "We describe structural properties and biological activities of two related O-glycosylated peptide toxins isolated from injected (milked) venom of Conus striatus, a piscivorous snail that captures prey by injecting a venom that induces a violent, spastic paralysis. One 30 amino acid toxin is identified as kappaA-SIVA (termed s4a here), and another 37 amino acid toxin, s4b, corresponds to a putative peptide encoded by a previously reported cDNA. We confirm the amino acid sequences and carry out structural analyses of both mature toxins using multiple mass spectrometric techniques. These include electrospray ionization ion-trap mass spectrometry and nanoelectrospray techniques for small volume samples, as well as matrix-assisted laser desorption/ionization time of flight mass spectrometric analysis as a complementary method to assist in the determination of posttranslational modifications, including O-linked glycosylation. Physiological experiments indicate that both s4a and s4b induce intense repetitive firing of the frog neuromuscular junction, leading to a tetanic contracture in muscle fiber. These effects apparently involve modification of voltage-gated sodium channels in motor axons. Notably, application of either s4a or s4b alone mimics the biological effects of the whole injected venom on fish prey."xsd:string |
| http://purl.uniprot.org/citations/17115716 | http://purl.org/dc/terms/identifier | "doi:10.1021/bi061485s"xsd:string |
| http://purl.uniprot.org/citations/17115716 | http://purl.org/dc/terms/identifier | "doi:10.1021/bi061485s"xsd:string |
| http://purl.uniprot.org/citations/17115716 | http://purl.uniprot.org/core/author | "Sweedler J.V."xsd:string |
| http://purl.uniprot.org/citations/17115716 | http://purl.uniprot.org/core/author | "Sweedler J.V."xsd:string |
| http://purl.uniprot.org/citations/17115716 | http://purl.uniprot.org/core/author | "Gilly W.F."xsd:string |
| http://purl.uniprot.org/citations/17115716 | http://purl.uniprot.org/core/author | "Gilly W.F."xsd:string |
| http://purl.uniprot.org/citations/17115716 | http://purl.uniprot.org/core/author | "Jakubowski J.A."xsd:string |
| http://purl.uniprot.org/citations/17115716 | http://purl.uniprot.org/core/author | "Jakubowski J.A."xsd:string |
| http://purl.uniprot.org/citations/17115716 | http://purl.uniprot.org/core/author | "Kelley W.P."xsd:string |
| http://purl.uniprot.org/citations/17115716 | http://purl.uniprot.org/core/author | "Kelley W.P."xsd:string |
| http://purl.uniprot.org/citations/17115716 | http://purl.uniprot.org/core/author | "Schulz J.R."xsd:string |
| http://purl.uniprot.org/citations/17115716 | http://purl.uniprot.org/core/author | "Schulz J.R."xsd:string |
| http://purl.uniprot.org/citations/17115716 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17115716 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17115716 | http://purl.uniprot.org/core/name | "Biochemistry"xsd:string |
| http://purl.uniprot.org/citations/17115716 | http://purl.uniprot.org/core/name | "Biochemistry"xsd:string |
| http://purl.uniprot.org/citations/17115716 | http://purl.uniprot.org/core/pages | "14212-14222"xsd:string |
| http://purl.uniprot.org/citations/17115716 | http://purl.uniprot.org/core/pages | "14212-14222"xsd:string |
| http://purl.uniprot.org/citations/17115716 | http://purl.uniprot.org/core/title | "Two toxins from Conus striatus that individually induce tetanic paralysis."xsd:string |
| http://purl.uniprot.org/citations/17115716 | http://purl.uniprot.org/core/title | "Two toxins from Conus striatus that individually induce tetanic paralysis."xsd:string |
| http://purl.uniprot.org/citations/17115716 | http://purl.uniprot.org/core/volume | "45"xsd:string |
| http://purl.uniprot.org/citations/17115716 | http://purl.uniprot.org/core/volume | "45"xsd:string |