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http://purl.uniprot.org/citations/17125826http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/17125826http://www.w3.org/2000/01/rdf-schema#comment"

Background

Although the mechanism that underlies aspirin hypersensitivity is not completely understood, an IgE-mediated response was reported for a patient with aspirin-intolerant chronic urticaria (AICU).

Objective

We investigated whether genetic polymorphisms on the alpha-chain of the high-affinity IgE receptor (FcepsilonRIalpha) gene were associated with the AICU phenotype.

Methods

We genotyped 2 promoter polymorphisms (-344C>T and -95T>C) of FcepsilonRIalpha gene in the Korean population, and the functional effect of the -344C>T polymorphism was analyzed by using a luciferase reporter assay and an electrophoretic mobility shift assay.

Results

The rare allele frequency of the -344C>T polymorphism was significantly higher in the patients with AICU compared with the other subjects (P= .008 for AICU vs aspirin-tolerant chronic urticaria; P= .03 for AICU vs controls). This polymorphism was also significantly associated with total serum IgE concentrations and a higher rate of atopy in the patients with AICU (P= .01 and .05, respectively). The reporter plasmid that carried the -344T allele exhibited significantly higher promoter activity in a rat mast cell line (RBL-2H3) compared with the promoter activity of the -344C allele (P< .001). We found that transcription factor Myc-associated zinc finger protein preferentially bound the -344C promoter. Moreover, patients with AICU with the heterozygous CT genotype of the -344C>T polymorphism exhibited greater anti-IgE-mediated histamine release compared with those with the homozygous CC genotype.

Conclusion

These results suggest that the -344C>T polymorphism of the FcepsilonRIalpha promoter may be associated with increased expression of FcepsilonRIalpha on mast cells and enhanced release of histamine.

Clinical implications

The FcepsilonRIalpha -344C>T polymorphism may contribute to the development of AICU."xsd:string
http://purl.uniprot.org/citations/17125826http://purl.org/dc/terms/identifier"doi:10.1016/j.jaci.2006.10.006"xsd:string
http://purl.uniprot.org/citations/17125826http://purl.uniprot.org/core/author"Kim S.H."xsd:string
http://purl.uniprot.org/citations/17125826http://purl.uniprot.org/core/author"Yoon H.J."xsd:string
http://purl.uniprot.org/citations/17125826http://purl.uniprot.org/core/author"Park H.S."xsd:string
http://purl.uniprot.org/citations/17125826http://purl.uniprot.org/core/author"Ye Y.M."xsd:string
http://purl.uniprot.org/citations/17125826http://purl.uniprot.org/core/author"Bae J.S."xsd:string
http://purl.uniprot.org/citations/17125826http://purl.uniprot.org/core/author"Nahm D.H."xsd:string
http://purl.uniprot.org/citations/17125826http://purl.uniprot.org/core/author"Suh C.H."xsd:string
http://purl.uniprot.org/citations/17125826http://purl.uniprot.org/core/date"2007"xsd:gYear
http://purl.uniprot.org/citations/17125826http://purl.uniprot.org/core/name"J Allergy Clin Immunol"xsd:string
http://purl.uniprot.org/citations/17125826http://purl.uniprot.org/core/pages"449-456"xsd:string
http://purl.uniprot.org/citations/17125826http://purl.uniprot.org/core/title"Significant association of FcepsilonRIalpha promoter polymorphisms with aspirin-intolerant chronic urticaria."xsd:string
http://purl.uniprot.org/citations/17125826http://purl.uniprot.org/core/volume"119"xsd:string
http://purl.uniprot.org/citations/17125826http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/17125826
http://purl.uniprot.org/citations/17125826http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/17125826
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