| http://purl.uniprot.org/citations/17128266 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17128266 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17128266 | http://www.w3.org/2000/01/rdf-schema#comment | "The secretion of neurotransmitters and neuropeptides is mediated by distinct organelles-synaptic vesicles (SVs) and dense-core vesicles (DCVs), respectively. Relatively little is known about the factors that differentially regulate SV and DCV secretion. Here we show that protein kinase C-1 (PKC-1), which is most similar to the vertebrate PKC eta and epsilon isoforms, regulates exocytosis of DCVs in Caenorhabditis elegans motor neurons. Mutants lacking PCK-1 activity had delayed paralysis induced by the acetylcholinesterase inhibitor aldicarb, whereas mutants with increased PKC-1 activity had more rapid aldicarb-induced paralysis. Imaging and electrophysiological assays indicated that SV release occurred normally in pkc-1 mutants. By contrast, genetic analysis of aldicarb responses and imaging of fluorescently tagged neuropeptides indicated that mutants lacking PKC-1 had reduced neuropeptide secretion. Similar neuropeptide secretion defects were found in mutants lacking unc-31 (encoding the protein CAPS) or unc-13 (encoding Munc13). These results suggest that PKC-1 selectively regulates DCV release from neurons."xsd:string |
| http://purl.uniprot.org/citations/17128266 | http://purl.org/dc/terms/identifier | "doi:10.1038/nn1810"xsd:string |
| http://purl.uniprot.org/citations/17128266 | http://purl.org/dc/terms/identifier | "doi:10.1038/nn1810"xsd:string |
| http://purl.uniprot.org/citations/17128266 | http://purl.uniprot.org/core/author | "Kaplan J.M."xsd:string |
| http://purl.uniprot.org/citations/17128266 | http://purl.uniprot.org/core/author | "Kaplan J.M."xsd:string |
| http://purl.uniprot.org/citations/17128266 | http://purl.uniprot.org/core/author | "Madison J.M."xsd:string |
| http://purl.uniprot.org/citations/17128266 | http://purl.uniprot.org/core/author | "Madison J.M."xsd:string |
| http://purl.uniprot.org/citations/17128266 | http://purl.uniprot.org/core/author | "Sieburth D."xsd:string |
| http://purl.uniprot.org/citations/17128266 | http://purl.uniprot.org/core/author | "Sieburth D."xsd:string |
| http://purl.uniprot.org/citations/17128266 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17128266 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17128266 | http://purl.uniprot.org/core/name | "Nat. Neurosci."xsd:string |
| http://purl.uniprot.org/citations/17128266 | http://purl.uniprot.org/core/name | "Nat. Neurosci."xsd:string |
| http://purl.uniprot.org/citations/17128266 | http://purl.uniprot.org/core/pages | "49-57"xsd:string |
| http://purl.uniprot.org/citations/17128266 | http://purl.uniprot.org/core/pages | "49-57"xsd:string |
| http://purl.uniprot.org/citations/17128266 | http://purl.uniprot.org/core/title | "PKC-1 regulates secretion of neuropeptides."xsd:string |
| http://purl.uniprot.org/citations/17128266 | http://purl.uniprot.org/core/title | "PKC-1 regulates secretion of neuropeptides."xsd:string |
| http://purl.uniprot.org/citations/17128266 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/17128266 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/17128266 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17128266 |
| http://purl.uniprot.org/citations/17128266 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17128266 |
| http://purl.uniprot.org/citations/17128266 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17128266 |
| http://purl.uniprot.org/citations/17128266 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17128266 |