| http://purl.uniprot.org/citations/17130235 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17130235 | http://www.w3.org/2000/01/rdf-schema#comment | "The C-terminal fragment of the beta-amyloid precursor protein produced after cleavage by gamma-secretase, namely, APPct or AICD, has been shown to form a multimeric complex with the adaptor protein Fe65 and to regulate transcription through the recruitment of the histone acetyltransferase Tip60. The present study shows that 17beta-estradiol inhibits the transcriptional and apoptotic activities of the APPct complex by a process involving the interaction of estrogen receptor alpha (ERalpha) with Fe65. ERalpha-Fe65 complexes were detected both in vitro and in the mouse brain, and recruitment of ERalpha to the promoter of an APPct target gene (KAI1) was demonstrated. Our studies reveal a novel mechanism of estrogen action, which may explain the well-known neuroprotective functions of estrogens as well as the complex role of this female hormone in the pathogenesis of neuronal degeneration diseases."xsd:string |
| http://purl.uniprot.org/citations/17130235 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.01280-06"xsd:string |
| http://purl.uniprot.org/citations/17130235 | http://purl.uniprot.org/core/author | "Bao J."xsd:string |
| http://purl.uniprot.org/citations/17130235 | http://purl.uniprot.org/core/author | "Cao C."xsd:string |
| http://purl.uniprot.org/citations/17130235 | http://purl.uniprot.org/core/author | "Jiang F."xsd:string |
| http://purl.uniprot.org/citations/17130235 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/17130235 | http://purl.uniprot.org/core/author | "Bai W."xsd:string |
| http://purl.uniprot.org/citations/17130235 | http://purl.uniprot.org/core/author | "Nicosia S.V."xsd:string |
| http://purl.uniprot.org/citations/17130235 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17130235 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/17130235 | http://purl.uniprot.org/core/pages | "1321-1333"xsd:string |
| http://purl.uniprot.org/citations/17130235 | http://purl.uniprot.org/core/title | "Suppression of beta-amyloid precursor protein signaling into the nucleus by estrogens mediated through complex formation between the estrogen receptor and Fe65."xsd:string |
| http://purl.uniprot.org/citations/17130235 | http://purl.uniprot.org/core/volume | "27"xsd:string |
| http://purl.uniprot.org/citations/17130235 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17130235 |
| http://purl.uniprot.org/citations/17130235 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17130235 |
| http://purl.uniprot.org/uniprot/#_A0A125SXW0-mappedCitation-17130235 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17130235 |
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