| http://purl.uniprot.org/citations/17130290 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17130290 | http://www.w3.org/2000/01/rdf-schema#comment | "Fas receptor is a member of the tumor necrosis factor-alpha family of death receptors that mediate physiologic apoptotic signaling. To investigate the molecular mechanisms regulating calcium mobilization during Fas-mediated apoptosis, we have analyzed the sequential steps leading to altered calcium homeostasis and cell death in response to activation of the Fas receptor. We show that Fas-mediated apoptosis requires endoplasmic reticulum-mediated calcium release in a mechanism dependent on phospholipase C-gamma1 (PLC-gamma1) activation and Ca2+ release from inositol 1,4,5-trisphosphate receptor (IP3R) channels. The kinetics of Ca2+ release were biphasic, demonstrating a rapid elevation caused by PLC-gamma1 activation and a delayed and sustained increase caused by cytochrome c binding to IP3R. Blocking either phase of Ca2+ mobilization was cytoprotective, highlighting PLC-gamma1 and IP3R as possible therapeutic targets for disorders associated with Fas signaling."xsd:string |
| http://purl.uniprot.org/citations/17130290 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200608035"xsd:string |
| http://purl.uniprot.org/citations/17130290 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/17130290 | http://purl.uniprot.org/core/author | "Boehning D."xsd:string |
| http://purl.uniprot.org/citations/17130290 | http://purl.uniprot.org/core/author | "Stieren E.S."xsd:string |
| http://purl.uniprot.org/citations/17130290 | http://purl.uniprot.org/core/author | "Elferink C.J."xsd:string |
| http://purl.uniprot.org/citations/17130290 | http://purl.uniprot.org/core/author | "Wozniak A.L."xsd:string |
| http://purl.uniprot.org/citations/17130290 | http://purl.uniprot.org/core/author | "Scarbrough S.G."xsd:string |
| http://purl.uniprot.org/citations/17130290 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17130290 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/17130290 | http://purl.uniprot.org/core/pages | "709-714"xsd:string |
| http://purl.uniprot.org/citations/17130290 | http://purl.uniprot.org/core/title | "Requirement of biphasic calcium release from the endoplasmic reticulum for Fas-mediated apoptosis."xsd:string |
| http://purl.uniprot.org/citations/17130290 | http://purl.uniprot.org/core/volume | "175"xsd:string |
| http://purl.uniprot.org/citations/17130290 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17130290 |
| http://purl.uniprot.org/citations/17130290 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17130290 |
| http://purl.uniprot.org/uniprot/#_B4DGH1-mappedCitation-17130290 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17130290 |
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| http://purl.uniprot.org/uniprot/#_Q4LE43-mappedCitation-17130290 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17130290 |
| http://purl.uniprot.org/uniprot/#_P19174-mappedCitation-17130290 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17130290 |
| http://purl.uniprot.org/uniprot/#_Q59H91-mappedCitation-17130290 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17130290 |