| http://purl.uniprot.org/citations/17135331 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17135331 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17135331 | http://www.w3.org/2000/01/rdf-schema#comment | "The superfamily of serine protease inhibitors (SERPINs) plays a key role in controlling the activity of proteinases in diverse biological processes. alpha1-antitrypsin (SERPINA1), the most studied member of this family, is encoded by a gene located within the proximal 14q32.1 SERPIN subcluster, together with the highly homologous alpha1-antitrypsin-like sequence (SERPINA2), which was previously proposed to be a pseudogene. Here, we performed a resequencing study encompassing both SERPINA1 and SERPINA2 as well as the adjacent gene coding for corticosteroid-binding globulin (SERPINA6) in samples from Europe and West Africa. In the African sample, we found that a common haplotype carrying a 2-kb deletion in the SERPINA2 gene is associated with remarkable long-range homozygozity as if it was quickly driven to high frequency by natural selection acting on an advantageous variant. An analysis of the HapMap Phase I data for the Yoruba sample confirmed that variation in this subcluster carries a strong signal of positive selection. We also show that the SERPINA2 gene is expressed and probably encodes a functional SERPIN. Finally, comparisons with orthologous sequences in nonhuman primates showed that SERPINA2 is present in some great apes, but in chimpanzees it was lost by a deletion event independent from that observed in humans. In agreement with the "less is more" hypothesis, we propose that loss of SERPINA2 is an ongoing process associated with a selective advantage during recent primate evolution, possibly because of a role in fertility or in host-pathogen interactions."xsd:string |
| http://purl.uniprot.org/citations/17135331 | http://purl.org/dc/terms/identifier | "doi:10.1093/molbev/msl187"xsd:string |
| http://purl.uniprot.org/citations/17135331 | http://purl.org/dc/terms/identifier | "doi:10.1093/molbev/msl187"xsd:string |
| http://purl.uniprot.org/citations/17135331 | http://purl.uniprot.org/core/author | "Carvalho F."xsd:string |
| http://purl.uniprot.org/citations/17135331 | http://purl.uniprot.org/core/author | "Carvalho F."xsd:string |
| http://purl.uniprot.org/citations/17135331 | http://purl.uniprot.org/core/author | "Di Rienzo A."xsd:string |
| http://purl.uniprot.org/citations/17135331 | http://purl.uniprot.org/core/author | "Di Rienzo A."xsd:string |
| http://purl.uniprot.org/citations/17135331 | http://purl.uniprot.org/core/author | "Rocha J."xsd:string |
| http://purl.uniprot.org/citations/17135331 | http://purl.uniprot.org/core/author | "Rocha J."xsd:string |
| http://purl.uniprot.org/citations/17135331 | http://purl.uniprot.org/core/author | "Seixas S."xsd:string |
| http://purl.uniprot.org/citations/17135331 | http://purl.uniprot.org/core/author | "Seixas S."xsd:string |
| http://purl.uniprot.org/citations/17135331 | http://purl.uniprot.org/core/author | "Seruca R."xsd:string |
| http://purl.uniprot.org/citations/17135331 | http://purl.uniprot.org/core/author | "Seruca R."xsd:string |
| http://purl.uniprot.org/citations/17135331 | http://purl.uniprot.org/core/author | "Suriano G."xsd:string |
| http://purl.uniprot.org/citations/17135331 | http://purl.uniprot.org/core/author | "Suriano G."xsd:string |
| http://purl.uniprot.org/citations/17135331 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17135331 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17135331 | http://purl.uniprot.org/core/name | "Mol. Biol. Evol."xsd:string |
| http://purl.uniprot.org/citations/17135331 | http://purl.uniprot.org/core/name | "Mol. Biol. Evol."xsd:string |
| http://purl.uniprot.org/citations/17135331 | http://purl.uniprot.org/core/pages | "587-598"xsd:string |
| http://purl.uniprot.org/citations/17135331 | http://purl.uniprot.org/core/pages | "587-598"xsd:string |
| http://purl.uniprot.org/citations/17135331 | http://purl.uniprot.org/core/title | "Sequence diversity at the proximal 14q32.1 SERPIN subcluster: evidence for natural selection favoring the pseudogenization of SERPINA2."xsd:string |
| http://purl.uniprot.org/citations/17135331 | http://purl.uniprot.org/core/title | "Sequence diversity at the proximal 14q32.1 SERPIN subcluster: evidence for natural selection favoring the pseudogenization of SERPINA2."xsd:string |