| http://purl.uniprot.org/citations/17135575 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17135575 | http://www.w3.org/2000/01/rdf-schema#comment | "An anti-inflammatory effect of PGI(2) has been suggested by increased inflammation in mice that are deficient in the PGI(2) receptor (IP) or in respiratory syncytial viral- or OVA-induced CD4 T cell-associated responses. To determine the mechanism of the anti-inflammatory effect, we hypothesized that PGI(2) analogs inhibit CD4 T cell effector cytokine production. To test this hypothesis, we activated purified CD4 T cells with anti-CD3 and anti-CD28 antibodies under Th1 and Th2 polarizing conditions for 4 days and restimulated the T cells with anti-CD3 in the presence of PGI(2) analogs for 2 days. We found that PGI(2) analogs (cicaprost and iloprost) inhibited the production of Th1 cytokines (IFN-gamma) and Th2 cytokines (IL-4, IL-10, and IL-13) in a dose-dependent pattern. The inhibitory effect was partially dependent on the IP receptor signaling and was correlated with elevated intracellular cAMP and down-regulated NF-kappaB activity. Pretreatment of the CD4 T cells with 8-bromoadenosine-3',5'-cyclic monophosphorothioate, Rp-isomer, to inhibit a key signaling molecule in the cAMP pathway, protein kinase A (PKA), attenuated the suppressive effect of PGI(2) analogs significantly, suggesting that PKA, in part, mediates the inhibition of the cytokine production. These data indicate that PGI(2) analogs have an immune-suppressive effect on previously activated and differentiated CD4 T cells in vitro and suggest that PGI(2) may have a similar function in vivo."xsd:string |
| http://purl.uniprot.org/citations/17135575 | http://purl.org/dc/terms/identifier | "doi:10.1189/jlb.0606375"xsd:string |
| http://purl.uniprot.org/citations/17135575 | http://purl.uniprot.org/core/author | "Zhou W."xsd:string |
| http://purl.uniprot.org/citations/17135575 | http://purl.uniprot.org/core/author | "Blackwell T.S."xsd:string |
| http://purl.uniprot.org/citations/17135575 | http://purl.uniprot.org/core/author | "Fitzgerald G.A."xsd:string |
| http://purl.uniprot.org/citations/17135575 | http://purl.uniprot.org/core/author | "Breyer R.M."xsd:string |
| http://purl.uniprot.org/citations/17135575 | http://purl.uniprot.org/core/author | "Goleniewska K."xsd:string |
| http://purl.uniprot.org/citations/17135575 | http://purl.uniprot.org/core/author | "O'Neal J.F."xsd:string |
| http://purl.uniprot.org/citations/17135575 | http://purl.uniprot.org/core/author | "Peebles R.S. Jr."xsd:string |
| http://purl.uniprot.org/citations/17135575 | http://purl.uniprot.org/core/author | "Lucitt M."xsd:string |
| http://purl.uniprot.org/citations/17135575 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17135575 | http://purl.uniprot.org/core/name | "J Leukoc Biol"xsd:string |
| http://purl.uniprot.org/citations/17135575 | http://purl.uniprot.org/core/pages | "809-817"xsd:string |
| http://purl.uniprot.org/citations/17135575 | http://purl.uniprot.org/core/title | "Prostaglandin I2 analogs inhibit Th1 and Th2 effector cytokine production by CD4 T cells."xsd:string |
| http://purl.uniprot.org/citations/17135575 | http://purl.uniprot.org/core/volume | "81"xsd:string |
| http://purl.uniprot.org/citations/17135575 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17135575 |
| http://purl.uniprot.org/citations/17135575 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17135575 |
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